tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate

Base Information

Chemical Name:tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate
CAS No.:1202757-90-1
Molecular Formula:C₂₇H₃₁FN₆O₄
Molecular Weight:522.579
Hs Code.:

Synonyms:tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate

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Chemical Property of tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate

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Technology Process of tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate

There total 8 articles about tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

: 1202760-21-1
C₂₄H₂₉FN₆O₃

: 814-68-6,25189-84-8
acryloyl chloride

: 1202757-90-1
tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 0.5h;

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1202757-90-1
tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

4: acetic acid / ethanol / 48 h / 90 °C

5: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

6: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C

With hydrogen; potassium carbonate; acetic acid; triethylamine; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1035452-25-5
tert-butyl 3-(3-nitrophenoxy)propylcarbamate

: 1202757-90-1
tert-butyl 3-(3-(4-(3-acrylamidophenylamino)-5-fluoropyrimidin-2-ylamino)phenoxy)propylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

2: acetic acid / ethanol / 48 h / 90 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

4: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C

With hydrogen; potassium carbonate; acetic acid; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol;