methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate

Base Information

• Chemical Name: methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate
• CAS No.: 250601-46-8
• Molecular Formula: C₃₀H₃₀N₂O₅
• Molecular Weight: 498.579
• Mol file: 250601-46-8.mol

Synonyms:methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate

Chemical Property of methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate

There total 7 articles about methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ethyl acetate n-hexane + 4-[2-(4-Chloromethyl-phenoxy)-ethyl]-5-methyl-2-phenyl-oxazole (132646-28-7) + methyl (E)-4-hydroxyimino-4-phenylbutyrate (250602-56-3) → methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate (250601-46-8)

Guidance literature:

With hydrogenchloride; sodium chloride; sodium hydrogencarbonate; In N,N-dimethyl-formamide;

Reference yield: 26.0%

4-[2-(4-Chloromethyl-phenoxy)-ethyl]-5-methyl-2-phenyl-oxazole (132646-28-7) + methyl (E)-4-hydroxyimino-4-phenylbutyrate (250602-56-3) → methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate (250601-46-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

DOI:10.1248/cpb.51.138

Reference yield:

3-benzoylpropionic acid methyl ester (25333-24-8) → methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate (250601-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / hydroxylamine hydrochloride; sodium acetate / methanol / 8 h / Heating

2: 26 percent / sodium hydride / dimethylformamide / 2 h / 0 °C

With hydroxylamine hydrochloride; sodium acetate; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.51.138

upstream raw materials:

4-[2-(4-Chloromethyl-phenoxy)-ethyl]-5-methyl-2-phenyl-oxazole

methyl (E)-4-hydroxyimino-4-phenylbutyrate

3-benzoylpropionic acid methyl ester

4-fluorobenzaldehyde