25333-24-8

Usage

Uses

Used in Chemical Industry:
METHYL 3-BENZOYLPROPIONATE is used as a chemical intermediate for the synthesis of various compounds and materials. Its chemical structure allows it to be a versatile building block in the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
METHYL 3-BENZOYLPROPIONATE is used as an organic intermediate in the development of new drugs and pharmaceutical compounds. Its unique properties enable it to be a key component in the synthesis of novel therapeutic agents, potentially contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
METHYL 3-BENZOYLPROPIONATE is used as an organic intermediate in the formulation of agrochemicals, such as pesticides and herbicides. Its role in these products helps to improve the efficiency and effectiveness of these chemicals in agricultural applications.
Used in Specialty Chemicals Industry:
METHYL 3-BENZOYLPROPIONATE is used as a chemical intermediate in the production of specialty chemicals, which are tailored to meet specific requirements in various industries, such as cosmetics, coatings, and plastics. Its unique properties make it a valuable component in the development of these specialized products.

InChI:InChI=1/C11H12O3/c1-14-11(13)8-7-10(12)9-5-3-2-4-6-9/h2-6H,7-8H2,1H3

Upstream product

• 41158-32-1 methyl 4-oxo-4-phenylbut-2-ynoate 
• 67-56-1 methanol 
• 2051-95-8 succinylbenzene 
• 124-41-4 sodium methylate 
• 186581-53-3 diazomethane 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 56346-03-3 C₁₁H₁₄LiNOSi 
• 22049-87-2 rac-4-nitro-4-phenyl-butyric acid methyl ester 
• 38447-68-6 phenyl selenobenzoate 
• 292638-85-8 acrylic acid methyl ester 
• 26551-48-4 Methyl 3-bromo-4-keto-4-phenylbutanoate 
• 77-78-1 dimethyl sulfate 
• 17277-58-6 methyl (phenylsulfanyl)acetate 

Downstream Products

• 24459-27-6 2-methyl-5-phenylhexane-2,5-diol 
• 53774-19-9 4-phenyl-3-pentenoic acid 
• 14274-07-8 methyl 3-benzoylacrylate 
• 16115-36-9 4-(2-oxo-5-phenyl-1,2-dihydro-pyrrol-3-ylidene)-4-phenyl-butyric acid methyl ester 
• 134953-19-8 (E)-4-phenylhex-3-enoic acid 
• 63469-15-8 1,1,4,4-tetraphenyl-1,4-butanediol 
• 4850-50-4 1-phenyl-butane-1,4-diol 
• 2051-95-8 succinylbenzene 
• 26551-48-4 Methyl 3-bromo-4-keto-4-phenylbutanoate 
• 860361-30-4 1-phenethyl-5-phenyl-pyrrolidin-2-one 
• 39755-03-8 4-hydroxy-1-phenyl-butan-1-one 
• 939-52-6 4-chloro-1-phenylbutan-1-one 
• 103632-91-3 2-[2-(methoxycarbonyl)ethyl]-2-phenyl-1,3-dioxolane 
• 67545-37-3 4-hydroxy-4-phenyl-hexanoic acid 

Relevant academic research and scientific papers

3,6-bis(triphenylphosphonium)cyclohexene peroxodisulfate: A highly efficient oxidant for the selective oxidation of benzylic alcohols

The synthesis of 3,6-bis(triphenylphosphonium)cyclohexene peroxodisulfate and its application for the selective oxidation of benzylic alcohols is reported.

Reaction of iron aminocarbene complexes with electronically deficient alkenes

Thermal reaction of iron aminocarbene complexes bearing aromatic substituent (CO)4Fe=C(Ar)N(CH3)2 with methyl acrylate, acrylonitrile and methyl vinyl ketone furnishes 1,4-dicarbonyl compounds - formal products of Michael

Photoinduced Deaminative Alkylation for the Synthesis of γ-Ketoesters via Electron Donor–Acceptor Complex Formation

Visible-light-induced deaminative alkylation of Katritzky salts with silyl enol ethers has been developed. The reaction can proceed efficiently through electron donor–acceptor complex formation, avoiding the use of precious metal complexes or synthetically elaborate organic dyes. A series of functionalized γ-ketoesters was successfully obtained with good functional group tolerance and compatibility under mild and straightforward conditions.

Metal-free reduction of unsaturated carbonyls, quinones, and pyridinium salts with tetrahydroxydiboron/water

A series of unsaturated carbonyls, quinones, and pyridinium salts have been effectively reduced to the corresponding saturated carbonyls, dihydroxybenzenes, and hydropyridines in moderate to high yields with tetrahydroxydiboron/water as a mild, convenient, and metal-free reduction system. Deuterium-labeling experiments have revealed this protocol to be an exclusive transfer hydrogenation process from water. This journal is

Visible-Spectrum Solar-Light-Mediated Benzylic C-H Oxygenation Using 9,10-Dibromoanthracene As an Initiator

We report a visible-light-mediated benzylic C-H oxygenation reaction. The reaction is initiated by solar light or the blue LED activation of 9,10-dibromoanthracene in a reaction with oxygen and takes place at ambient temperature and air pressure. Secondary benzylic positions are oxygenated to ketones, while tertiary benzylic carbons are oxygenated to give hydroperoxides. Notably, cumene hydroperoxide is produced in a higher yield and at milder conditions than the currently employed industrial conditions.

Tandem homologation-acylation chemistry: Single and double homologation

Treatment of β-dicarbonyls with the Furakawa-variant of the Simmons-Smith reagent results in homologation and production of an intermediate zinc enolate. Treatment of the enolate with various acylating agents generate products with both γ-dicarbonyl funct

LIGHT INDUCED CATALYTIC C-H OXYGENATION OF ALKANES

A method of oxygenating a benzylic C-H bond is provided. The method comprises light induced activation of an initiator and subsequent reaction with oxygen, resulting in the formation of free radicals. Subsequently, free radicals catalyze the reaction of the benzylic C-H bond with oxygen, thereby forming an oxygenated compound.

Transition Metal-Free Alkyne-Aldehyde Reductive C?C Coupling trough Cascade Borylation/Olefin Isomerization

A direct approach to γ-keto esters through cascade alkyne-aldehyde reductive C?C coupling of propargyl esters and aromatic aldehydes under transition-metal-free (TM-free) fashion was developed. Compared with multistep processes, this procedure provides a

Direct Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters

Lactams with a stereogenic center adjacent to the N atom have existed in many medicinal agents and bioactive alkaloids. Herein we report a broadly applicable synthesis of enantioenriched NH lactams through a one-pot asymmetric reductive amination/cyclization sequence of easily available keto acids/esters. Such cascade processes alleviate the demand for protecting group manipulations as well as intermediate purification. This strategy is capable of constructing enantioenriched lactams and benzo-lactams of a five-, six-, or seven-membered ring in generally high yield and with excellent enantioselectivities (up to 97% ee). Scalable and concise syntheses of key drug intermediates have further displayed the importance of this methodology.

Biocatalytic Asymmetric Reduction of γ-Keto Esters to Access Optically Active γ-Aryl-γ-butyrolactones

An efficient stereoselective syntheses of a series of functionalized optically active γ-aryl-γ-butyrolactones is achieved by enzymatic asymmetric reduction of the corresponding sterically demanding γ-keto esters employing wild-type and recombinant alcohol dehydrogenases. The best stereoselectivities for the reduction via hydrogen transfer was obtained with two short chain dehydrogenases (SDRs) of complementary stereospecificity from Aromatoleum aromaticum, namely the Prelog-specific NADH-dependent (S)-1-phenylethanol dehydrogenase [(S)-PED] and the anti-Prelog-specific (R)-1-(4-hydroxyphenyl)-ethanol dehydrogenase [(R)-HPED], respectively.Biotransformations catalyzed by both enzymes, followed by TFA-catalyzed cyclization of the resulting γ-hydroxy esters, furnished the respective (S)- and (R)-configured products with exquisite optical purity (up to >99% ee). The synthetic value was demonstrated on preparative scale for the asymmetric bioreduction of the model compound, methyl 4-oxo-4-phenylbutanoate, affording optically pure (S)-γ-phenyl-γ-butyrolactone (>99% ee) in 67–74% isolated yield at 89–95% conversion depending on the applied scale. (Figure presented.).