α-nitro-p-chloroisobutyrophenone

Base Information

• Chemical Name: α-nitro-p-chloroisobutyrophenone
• CAS No.: 74261-44-2
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.647
• Mol file: 74261-44-2.mol

Synonyms:α-nitro-p-chloroisobutyrophenone

Chemical Property of α-nitro-p-chloroisobutyrophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-nitro-p-chloroisobutyrophenone

There total 1 articles about α-nitro-p-chloroisobutyrophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-chloro-α-(1-methyl-1-nitroethyl)benzenemethanol (33682-87-0) → α-nitro-p-chloroisobutyrophenone (74261-44-2)

Guidance literature:

With sodium dichromate; sulfuric acid; In water; Ambient temperature;

DOI:10.1021/ja00350a045

Reference yield: 91.0%

α-nitro-p-chloroisobutyrophenone (74261-44-2) → 1-(4-chlorophenyl)-2-methylpropan-1-one (18713-58-1)

Guidance literature:

With 1-Benzyl-1,4-dihydronicotinamide; In N,N-dimethyl-formamide; for 24h; Ambient temperature; Irradiation;

DOI:10.1021/ja00528a062

Reference yield:

α-nitro-p-chloroisobutyrophenone (74261-44-2) → 1-(4-chlorophenyl)-2-methylpropan-1-one (18713-58-1) + C10H10(2)HClO

Guidance literature:

With triethylsilane; sodium dithionite; In N,N,N,N,N,N-hexamethylphosphoric triamide; water-d2; at 25 ℃; for 3h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(01)80517-7

upstream raw materials:

4-chloro-α-(1-methyl-1-nitroethyl)benzenemethanol

Downstream raw materials:

1-(4-chlorophenyl)-2-methylpropan-1-one

Refernces