3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

Base Information

Chemical Name:3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester
CAS No.:1383729-67-6
Molecular Formula:C₂₉H₂₈N₆O₅S
Molecular Weight:572.645
Hs Code.:

3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

Synonyms:3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

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Chemical Property of 3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

There total 8 articles about 3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1383729-66-5
3-benzenesulfonyl-8-oxo-9-piperidin-4-yl-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

: 3-(bromomethyl)pyridine monohydrochloride

: 1383729-67-6
3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 18h;

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1383729-67-6
3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dmap / dichloromethane / 18 - 25 °C

2: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 23.5 h / -5 - 25 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / Reflux

4: hydrogen / 20% palladium hydroxide-activated charcoal / acetic acid / 24 h / 50 °C / Inert atmosphere

5: toluene / 18 h / Reflux

6: trifluoroacetic acid / dichloromethane / 1 h / 18 - 25 °C

7: potassium carbonate / N,N-dimethyl-formamide / 18 h / 18 - 25 °C

With hydrogen; tetrabutylammonium nitrate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; dmap; 20% palladium hydroxide-activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1383729-67-6
3-benzenesulfonyl-8-oxo-9-(1-pyridin-3-ylmethyl-piperidin-4-yl)-8,9-dihydro-3H-3,4,6,9-tetraazacyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dmap / dichloromethane / 18 - 25 °C

2: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 23.5 h / -5 - 25 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / Reflux

4: hydrogen / 20% palladium hydroxide-activated charcoal / acetic acid / 24 h / 50 °C / Inert atmosphere

5: toluene / 18 h / Reflux

6: trifluoroacetic acid / dichloromethane / 1 h / 18 - 25 °C

7: potassium carbonate / N,N-dimethyl-formamide / 18 h / 18 - 25 °C

With hydrogen; tetrabutylammonium nitrate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; dmap; 20% palladium hydroxide-activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; toluene;