(3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one

Base Information

Chemical Name:(3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one
CAS No.:1312549-86-2
Molecular Formula:C₂₁H₂₇NO₄
Molecular Weight:357.45
Hs Code.:

Synonyms:(3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one

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Technology Process of (3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one

There total 4 articles about (3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₇NO₇S

: 1312549-86-2
(3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one

Guidance literature:: With triethylamine; benzylamine; In dimethyl sulfoxide; at 80 ℃; for 4h;
DOI:10.1016/j.tet.2011.04.027

Reference yield:

: 1312549-85-1
(4S,5S)-4-(benzyloxymethyl)-5-((R)-1-hydroxynon-2-ynyl)-3-(4-methoxybenzyl) oxazolidin-2-one

: 1312549-86-2
(3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; benzylamine / dimethyl sulfoxide / 4 h / 80 °C

With triethylamine; benzylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.04.027

Reference yield:

: 629-05-0
n-octyne

: 1312549-86-2
(3aS,6S,6aS)-3-(4-methoxybenzyl)-6-(oct-1-ynyl)tetrahydrofuro[3,4-d]oxazol-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -20 °C

1.2: 1 h / -78 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine; benzylamine / dimethyl sulfoxide / 4 h / 80 °C

With n-butyllithium; triethylamine; benzylamine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.04.027