2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine

Base Information

• Chemical Name: 2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine
• CAS No.: 1126431-57-9
• Molecular Formula: C₁₇H₁₆ClN₃OS
• Molecular Weight: 345.853

Synonyms:2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine

Chemical Property of 2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine

Chemical Property:

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Technology Process of 2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine

There total 1 articles about 2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

thioisobutyramide (13515-65-6) + 2-(2-chloro-4-pyrimidinyl)-1-[3-(methyloxy)phenyl]ethanone (1126431-01-3) → 2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine (1126431-57-9)

Guidance literature:

2-(2-chloro-4-pyrimidinyl)-1-[3-(methyloxy)phenyl]ethanone; With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

thioisobutyramide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 39.0%

(3-fluoro-4-{[1-(1-methylethyl)-4-piperidinyl]oxy}phenyl)amine (1126431-58-0) + 2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine (1126431-57-9) → N-(3-fluoro-4-{[1-(1-methylethyl)-4-piperidinyl]oxy}phenyl)-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}-2-pyrimidinamine (1126431-56-8)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 180 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

N-(2-pyrrolidin-1-ylethyl)benzene-1,4-diamine (863453-84-3) + 2-chloro-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}pyrimidine (1126431-57-9) → N-(4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}-2-pyrimidinyl)-N'-[2-(1-pyrrolidinyl)ethyl]-1,4-benzenediamine (1126432-19-6)

Guidance literature:

With hydrogenchloride; In Isopropyl acetate; at 180 ℃; for 0.25h; Microwave irradiation;

upstream raw materials:

thioisobutyramide

2-(2-chloro-4-pyrimidinyl)-1-[3-(methyloxy)phenyl]ethanone

Downstream raw materials:

N-(4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}-2-pyrimidinyl)-N'-[2-(1-pyrrolidinyl)ethyl]-1,4-benzenediamine

N-(3-fluoro-4-{[1-(1-methylethyl)-4-piperidinyl]oxy}phenyl)-4-{2-(1-methylethyl)-4-[3-(methyloxy)phenyl]-1,3-thiazol-5-yl}-2-pyrimidinamine

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