(3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile

Base Information

• Chemical Name: (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile
• CAS No.: 136262-53-8
• Molecular Formula: C₂₁H₂₇NOSi
• Molecular Weight: 337.537
• Mol file: 136262-53-8.mol

Synonyms:(3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile

Chemical Property of (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile

There total 8 articles about (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

sodium cyanide (773837-37-9) + (R)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2-methylpropane (186642-08-0) → (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile (136262-53-8)

Guidance literature:

In dimethyl sulfoxide; at 120 ℃; for 2h;

DOI:10.1021/jm901782m

Reference yield: 93.0%

sodium cyanide (143-33-9,25596-52-5) + (R)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2-methylpropane (186642-08-0) → (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile (136262-53-8)

Guidance literature:

In dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2007.09.081

Reference yield: 87.0%

potassium cyanide (151-50-8) + (R)-3-[(tert-butyl)diphenylsilyloxy]-1-iodo-2-methylpropane (123444-67-7) → (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile (136262-53-8)

Guidance literature:

In N,N-dimethyl-formamide; at 85 ℃;

DOI:10.1016/S0040-4039(01)80352-X

upstream raw materials:

sodium cyanide

(2R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl p-toluenesulfonate

Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

potassium cyanide

Downstream raw materials:

tert-butyl-((2S,6S)-2,6-dimethyltridecyloxy)-diphenyl silane

(S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutanal

(2S)-tert-butyl(2-methylpent-4-ynyloxy)diphenylsilane

(E)-(3S,7S,8S)-2-Benzenesulfonyl-8,9-bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one