Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

Base Information

Chemical Name:Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester
CAS No.:136292-93-8
Molecular Formula:C₂₁H₃₀O₄SSi
Molecular Weight:406.618
Hs Code.:

Synonyms:

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Chemical Property of Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

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Technology Process of Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

There total 2 articles about Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95514-03-7
(R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate

: 136292-93-8
Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: reduction

2: Et₃N

With triethylamine;
DOI:10.1021/jo00019a004

Reference yield:

: 95514-04-8,129029-85-2,120346-83-0
(S)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol

: 124-63-0
methanesulfonyl chloride

: 136292-93-8
Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

Guidance literature:: With triethylamine;
DOI:10.1021/jo00019a004

Reference yield:

: 136292-93-8
Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

: 136262-74-3
tert-Butyl-[(2S,4S)-4-methoxy-2-methyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 18 steps

1: NaI / dimethylsulfoxide

2: DIBAH / diethyl ether

4: DIBAH

5: L-(+)-DIPT, TBHP, TIP / -30 °C

6: Ph₃P, I₂, Im

7: n-BuLi / tetrahydrofuran / -78 deg C to room temp.

9: 1.) O₃, KOH / CH₂Cl₂

10: 78 percent

11: 80 percent / K₂CO₃ / 18-C-6 / toluene

12: Zn(BH₄)2 / diethyl ether / -45 °C

13: tetrahydrofuran / 0 °C

14: 87 percent / HOAc / tetrahydrofuran; H₂O

15: 91 percent / PPTS / acetone

16: O₃ / methanol; CH₂Cl₂

17: NaBH₄

18: Amberlyst-15 / acetone

With tert.-butylhydroperoxide; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; zinc(II) tetrahydroborate; amberlyst-15; L-(+)-diisopropyl tartrate; impramine; iodine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; isobutyltriphenylphosphonium bromide; potassium carbonate; ozone; acetic acid; triphenylphosphine; sodium iodide; 18-crown-6 ether; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetone; toluene;
DOI:10.1021/jo00019a004