(R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

Base Information

Chemical Name:(R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate
CAS No.:1459804-83-1
Molecular Formula:C₂₁H₂₄O₅
Molecular Weight:356.419
Hs Code.:

Synonyms:(R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

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Chemical Property of (R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

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Technology Process of (R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

There total 7 articles about (R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: methyl 2-(benzyloxy)-3-(2,3-dihydroxy-3-methylbutyl)-4-methoxybenzoate

: 1459804-83-1
(R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

Guidance literature:: methyl 2-(benzyloxy)-3-(2,3-dihydroxy-3-methylbutyl)-4-methoxybenzoate; With pyridine; methanesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 12h;

With potassium carbonate; In methanol; for 4h; Reflux;
DOI:10.1039/c3ob41497c

Reference yield:

: 1459804-79-5
methyl 2-(benzyloxy)-4-methoxy-3-(3-methylbut-2-en-1-yl)benzoate

: (S)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

: 1459804-83-1
(R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

Guidance literature:: With Oxone; Shi's ketone; potassium carbonate; tetrabutylammonium sulfate; In acetonitrile; at 0 ℃; for 16h; Temperature; Overall yield = 97 %;
DOI:10.1039/c3ob41497c

Reference yield:

: 100-39-0
benzyl bromide

: (S)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

: 1459804-83-1
(R)-methyl 2-(benzyloxy)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 16 h / Reflux

2: potassium carbonate; Shi's ketone; Oxone; tetrabutylammonium sulfate / acetonitrile / 16 h / 0 °C

With Oxone; Shi's ketone; potassium carbonate; tetrabutylammonium sulfate; In acetone; acetonitrile; 2: |Shi Asymmetric Epoxidation;
DOI:10.1039/c3ob41497c