triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate

Base Information

Chemical Name:triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate
CAS No.:1428553-41-6
Molecular Formula:C₆H₁₅N*C₃₄H₄₁N₂O₈PSi
Molecular Weight:765.959
Hs Code.:

Synonyms:triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate

Suppliers and Price of triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate

There total 6 articles about triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl bis-(2-cyanoethyl)boranophosphate

: 121-44-8
triethylamine

: 1428553-41-6
triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate

Guidance literature:: 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl bis-(2-cyanoethyl)boranophosphate; triethylamine; In acetonitrile; at 20 ℃; for 0.25h;

With dichloro-acetic acid; methoxy triphenylmethanol; In dichloromethane; at 0 ℃; for 0.166667h;

Reference yield: 51.0%

: 1428553-39-2
5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl (2-cyanoethyl) H-phosphonate

: 121-44-8
triethylamine

: 1428553-41-6
triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate

Guidance literature:: In acetonitrile; at 20 ℃; for 0.0833333h;
DOI:10.1016/j.tetlet.2013.02.054

Reference yield:

: 117136-35-3
2'-O-(tert-butyldimethylsilyl)-5'-O-(triphenylmethyl)uridine

: 1428553-41-6
triethylammonium 5’-O-trityl-2’-tertbutyldimethylsilyl-uridin-3’-yl H-phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus trichloride; 2,6-dimethylpyridine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

1.2: 0.33 h / -78 - -20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 0.5 h / -20 - 0 °C

3.1: acetonitrile / 0.25 h / 20 °C

4.1: tris(4-methoxyphenyl)methanol; dichloro-acetic acid / dichloromethane / 0.17 h / 0 °C

5.1: acetonitrile / 0.08 h / 20 °C

With 2,6-dimethylpyridine; dichloro-acetic acid; borane-THF; tris(4-methoxyphenyl)methanol; phosphorus trichloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2013.02.054