3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate

Base Information

Chemical Name:3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate
CAS No.:864719-77-7
Molecular Formula:C₂₃H₃₈O₇Si
Molecular Weight:454.636
Hs Code.:

Synonyms:3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate

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Chemical Property of 3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate

Chemical Property:

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Technology Process of 3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate

There total 4 articles about 3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: benzyl 2-(3-hydroxypropoxy)acetate

: 864719-75-5
{3-[(tert-butyldimethylsilyl)oxy]propoxy}acetic acid

: 864719-77-7
3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate

Guidance literature:: With dmap; camphor-10-sulfonic acid; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/j.tet.2005.06.034

Reference yield:

: 864719-75-5
{3-[(tert-butyldimethylsilyl)oxy]propoxy}acetic acid

: 864719-77-7
3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP; camphorsulfonic acid; DCC / CH₂Cl₂ / 3 h / 20 °C

2: 487 mg / HF / acetonitrile / 0 °C

3: 95 percent / DMAP; camphorsulfonic acid; DCC / CH₂Cl₂ / 5 h / 20 °C

With dmap; camphor-10-sulfonic acid; hydrogen fluoride; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2005.06.034

Reference yield:

: [3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-acetic acid benzyl ester

: 864719-77-7
3-{[benzyloxycarbonyl]methoxy}propyl 2-[3-(tert-butyldimethylsilyloxy)propoxy]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 487 mg / HF / acetonitrile / 0 °C

2: 95 percent / DMAP; camphorsulfonic acid; DCC / CH₂Cl₂ / 5 h / 20 °C

With dmap; camphor-10-sulfonic acid; hydrogen fluoride; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2005.06.034