3-((tert-Butyldimethylsilyl)oxy)propan-1-ol

Base Information

• Chemical Name: 3-((tert-Butyldimethylsilyl)oxy)propan-1-ol
• CAS No.: 73842-99-6
• Molecular Formula: C9H22 O2 Si
• Molecular Weight: 190.358
• Hs Code.: 2931900090
• European Community (EC) Number: 834-259-3
• DSSTox Substance ID: DTXSID60399088
• Nikkaji Number: J920.213G
• Mol file: 73842-99-6.mol

Synonyms:73842-99-6;3-((tert-Butyldimethylsilyl)oxy)propan-1-ol;3-(t-Butyldimethylsiloxy)propanol;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANOL;3-((tert-Butyldimethylsilyl)oxy)-propanol;3-[tert-butyl(dimethyl)silyl]oxypropan-1-ol;MFCD00187968;3-(T-Butyldimethylsiloxy)propan-1-ol;1-Propanol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-;3-(tert-Butyldimethylsiloxy)-1-propanol;3-(tert-butyldimethylsilyloxy)propan-1-ol;3-{[tert-butyl(dimethyl)silyl]oxy}propan-1-ol;3-[[tert-Butyl(dimethyl)silyl]oxy]-1-propanol;3-[(tert-butyldimethylsilyl)oxy]propan-1-ol;3-{[tert-butyl(dimethyl)silyl]oxy}-1-propanol;3-(tert-Butyldimethylsilanyloxy)propan-1-ol;SCHEMBL571057;3-t-butyldimethylsilyloxypropanol;DTXSID60399088;3-t-butlydimethylsiloxy-1-propanol;1,3-Propanediol, TBDMS derivative;1-t-butyldimethylsilyloxypropan-3-ol;3-(tert-butyldimethylsilyloxy)propanol;AKOS000279582;3-(t-butyldimethylsilyloxy)-l-propanol;CS-W007946;DS-7822;3-(t-butyldimethylsilyloxy)-1-propanol;3-(t-butyldimethylsilyloxy)propan-1-ol;3-(tert-butyldimethylsilyloxy)-propanol;s25089;3-[tert-butyl(dimethyl)silyloxy]propanol;3-{(tert-butyldimethylsilyl)oxy}propanol;SY041800;3-[(t-butyldimethylsilyl)oxy]-1-propanol;1-tert-Butyldimethylsilyloxy-3-hydroxypropane;B5555;FT-0641490;FT-0667435;3-(t-butyl-dimethyl-silanyloxy)-propan-1-ol;1,3-Propanediol, tert-butyldimethylsilyl ether;EN300-208481;3-((tert-Butyldimethylsilyl)oxy)-propanol, 97%;3-(tert-butyl-dimethyl-silanyloxy)-propan-1-ol;3-[dimethyl(1,1-dimethylethyl)siloxy]-propanol;3-{[(tert-butyl)(dimethyl)silyl]oxy}-1-propanol;A866017;2-(3-BROMOBENZOYLAMINO)BENZOICACIDMETHYLESTER;1-Propanol,3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-;3-[[dimethyl-(1,1-dimethylethyl)-silyl]-oxy]-propanol;3-Pyrrol[tert-butyl(dimethyl)silyl]oxymorphopropan-1-ol #

Chemical Property of 3-((tert-Butyldimethylsilyl)oxy)propan-1-ol

Chemical Property:

• Vapor Pressure: 0.0292mmHg at 25°C
• Refractive Index: n20/D 1.4350(lit.)
• Boiling Point: 110 °C6 mm Hg(lit.)
• PKA: 14.87±0.10(Predicted)
• Flash Point: 199 °F
• PSA: 29.46000
• Density: 0.892 g/mL at 25 °C(lit.)
• LogP: 2.39060
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane, Ether, Ethyl Acetate, Hexane, Methanol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 190.138906475
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-[(tert-Butyldimethylsilyl)oxy]-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OCCCO

Technology Process of 3-((tert-Butyldimethylsilyl)oxy)propan-1-ol

There total 4 articles about 3-((tert-Butyldimethylsilyl)oxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-tert-butyldimethylsilyloxy-3-triethylsilyloxypropane → 3-tert-butyldimethylsilyloxy-1-propanol (73842-99-6) + trimethyleneglycol (504-63-2)

Guidance literature:

With MCM-41; In methanol; for 4h; Ambient temperature;

Reference yield: 80.0%

3-tert-butyldimethylsilyloxy-1-propyl benzyl ether (203738-77-6) → 3-tert-butyldimethylsilyloxy-1-propanol (73842-99-6) + trimethyleneglycol (504-63-2)

Guidance literature:

With Ti-HMS; hydrogen; 5% Pd on active carbon; In methanol; for 4h; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(98)02145-5

Reference yield: 80.0%

tert-butyldimethylsilyl chloride (18162-48-6) + trimethyleneglycol (504-63-2) → 3-tert-butyldimethylsilyloxy-1-propanol (73842-99-6) + 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propane (82112-22-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 23 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.200802223

upstream raw materials:

3-tert-butyldimethylsilyloxy-1-propyl benzyl ether

tert-butyldimethylsilyl chloride

trimethyleneglycol

Downstream raw materials:

3-(tert-butyldimethylsilanyloxy)propionaldehyde

3-(tert-butyldimethylsilyloxy)propyl bromide

N-<3-(tert-butyldimethylsiloxy)propyl>-p-toluenesulfonate

(2R)-N-[(4Z)-{(1S)-3-(tert-butyldimethylsilyloxy)-1-hydroxyprop-1-yl]-8-benzyloxyocten-1-oyl}bornane-10,2-sultam

Refernces

• 1、 Itoh, Akichika,Kodama, Tomohiro,Masaki, Yukio. "Deprotection of a silyl group with mesoporous silica". . p. 861 - 864. Retrieved 2008/02/11.
• 2、 Itoh, Akichika,Kodama, Tomohiro,Masaki, Yukio. "Selective deprotection of triethylsilyl group in the presence of t-butyldimethylsilyl group with MCM-41/MeOH heterogeneous system". . p. 357 - 359. Retrieved 2007/10/03.