1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil

Base Information

Chemical Name:1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil
CAS No.:1039097-58-9
Molecular Formula:C₂₁H₂₃IN₂O₈
Molecular Weight:558.327
Hs Code.:

Synonyms:1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil

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Chemical Property of 1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil

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Technology Process of 1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil

There total 4 articles about 1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873957-41-6
1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]uracil

: 1039097-58-9
1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil

Guidance literature:: 1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]uracil; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

With iodine; In tetrahydrofuran; at -78 ℃; for 5h;

With acetic acid; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 34626-95-4
1,2:3,4-di-O-isopropylidene-β-D-psicofuranose

: 1039097-58-9
1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dmap / dichloromethane / 0 - 20 °C

2.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane / 4 h / 120 °C

2.2: 0 - 20 °C

2.3: 0.5 h

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

3.2: 5 h / -78 °C

3.3: 20 °C

With chloro-trimethyl-silane; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; dmap; In tetrahydrofuran; dichloromethane;

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 1039097-58-9
1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-6-iodouracil

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dmap / dichloromethane / 0 - 20 °C

2.1: chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane / 4 h / 120 °C

2.2: 0 - 20 °C

2.3: 0.5 h

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

3.2: 5 h / -78 °C

3.3: 20 °C

With chloro-trimethyl-silane; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; dmap; In tetrahydrofuran; dichloromethane;