(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate

Base Information

Chemical Name:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate
CAS No.:161266-94-0
Molecular Formula:C₂₄H₃₄O₂
Molecular Weight:354.533
Hs Code.:

Synonyms:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate

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Chemical Property of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate

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Technology Process of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate

There total 9 articles about (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2E,7E)-8-Iodo-octa-2,7-dienoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: 161266-94-0
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate

Guidance literature:: With triethyl borane; tri-n-butyl-tin hydride; bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; In hexane; toluene; at -20 ℃; for 2h; Yield given;
DOI:10.1016/0040-4039(94)02216-X

Reference yield:

: 161266-91-7
(+)-(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 8-iodoocta-2,7-dienoate

: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1S)-2-(cyclohex-2-ene)acetate

: 161266-94-0
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate

Guidance literature:: With n-butyl tin hydride; triethyl borane; bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; In cyclohexane; toluene; at -20 ℃; for 1h; Title compound not separated from byproducts;

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 161266-94-0
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: nBuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 94 percent / I₂ / hexane; tetrahydrofuran / 1.5 h / 20 °C

2.1: dipotassium azodicarboxylate; acetic acid / methanol; pyridine / 15 h / 0 °C

2.2: 48 percent / nBuNH₂ / CH₂Cl₂ / 12 h

3.1: 67 percent / PCC / CH₂Cl₂ / 1.5 h / 20 °C

4.1: NaH / tetrahydrofuran / 0.08 h / 0 °C

4.2: 89 percent / tetrahydrofuran / 3 h / 20 °C

5.1: methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide); BEt₃; n-BuSnH / toluene; cyclohexane / 1 h / -20 °C

With n-butyllithium; n-butyl tin hydride; triethyl borane; potassium diazodicarboxylate; bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; sodium hydride; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; cyclohexane; toluene; 1.1: Metallation / 1.2: Iodination / 2.1: Hydrogenation / 2.2: Reduction / 3.1: Dehydrogenation / 4.1: Metallation / 4.2: olefination / 5.1: Dehalogenation;