(S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline

Base Information

• Chemical Name: (S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline
• CAS No.: 210707-18-9
• Molecular Formula: C₂₅H₂₆N₂O₄S
• Molecular Weight: 450.558
• Mol file: 210707-18-9.mol

Synonyms:(S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline

Chemical Property of (S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline

There total 1 articles about (S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

L-Phenylalaninol (3182-95-4) + (S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid (4703-32-6) → (S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline (210707-18-9)

Guidance literature:

With pyridine; triethylamine; triphenylphosphine; In tetrachloromethane; acetonitrile; at 20 ℃; for 14h;

DOI:10.1021/jo000341v

Reference yield:

(S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline (210707-18-9) → N-[(S)-1-((S)-1-Hydroxymethyl-2-phenyl-ethyl)-2,8-dioxo-1-aza-spiro[4.5]deca-6,9-dien-3-yl]-4-methyl-benzenesulfonamide

Guidance literature:

With [bis(acetoxy)iodo]benzene; In various solvent(s); for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4039(98)00874-0

Reference yield:

(S)-4-benzyl-2-[(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl]-2-oxazoline (210707-18-9) → (3S,1S')-1-(2'-acetoxy-1'-benzylethyl)-3-[N-acetyl-N-(4-methylphenyl)sulfonylamino]-1-azaspiro[4.5]deca-6,9-diene-2,8-dione

Guidance literature:

Multi-step reaction with 2 steps

1: iodobenzene diacetate / 2,2,2-trifluoro-ethanol / 0.5 h / 25 °C

2: pyridine; 4-(dimethylamino)pyridine / 12 h / 20 °C

With pyridine; dmap; [bis(acetoxy)iodo]benzene; In 2,2,2-trifluoroethanol; 1: Oxidation / 2: Acetylation;

DOI:10.1021/jo000341v

upstream raw materials:

L-Phenylalaninol

(S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid