4703-32-6

Upstream product

• 101585-61-9 N-tosyl L-tyrosine methyl ester 
• 60-18-4 L-tyrosine 
• 98-59-9 p-toluenesulfonyl chloride 
• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 13504-90-0 (S)-2-((4-methylphenyl)sulfonamido)-3-(4-(tosyloxy)phenyl)propanoic acid 
• 58559-09-4 Ethyl N-(p-tosyl)tyrosinate 

Downstream Products

• 101719-83-9 3,5-bis-hydroxymethyl-N-(toluene-4-sulfonyl)-tyrosine 
• 102166-68-7 O-diethoxyphosphoryl-N-(toluene-4-sulfonyl)-L-tyrosine 
• 94997-54-3 N,O-dimethyl-N-(toluene-4-sulfonyl)-L-tyrosine 
• 101585-61-9 N-tosyl L-tyrosine methyl ester 
• 333999-50-1 (S)-2-{(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl}-4-(4-methoxybenzyl)-2-oxazoline 
• 122702-30-1 (2S,3S)-2-[(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-benzyloxycarbonyloxy-phenyl)-propionylamino]-3-methyl-pentanoic acid methyl ester 
• 122389-32-6 (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-benzyloxycarbonyloxy-phenyl)-propionic acid 4-nitro-phenyl ester 
• 91650-46-3 (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-benzyloxycarbonyloxy-phenyl)-propionic acid 
• 109369-51-9 (S)-2-Methylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionic acid 
• 110055-30-6 (S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionic acid tert-butyl ester 
• 537-49-5 N-methyl-L-tyrosine 
• 94917-43-8 (R)-3-Carboxymethylsulfanyl-2-[(S)-3-(4-hydroxy-phenyl)-2-(toluene-4-sulfonylamino)-propionylamino]-propionic acid 

Relevant academic research and scientific papers

Development of amino acid conjugated sulfonamides as potent antiulcer agent

A series of 2-{[(4-methylphenyl) sulfonyl] amino}-3-sulfanylpropanoic acid (1a) and its analogs 1b-j have been synthesized. These compounds were screened for their in vivo efficacy in pyloric ligation model. Compounds 1a and 1b with higher antiulcer potential were further screened in other gastric models to explore the mode of antiulcer action. To further understand the mode of action, in vitro inhibition of H+/K+ ATPase activity in gastric microsome isolated from rat stomach was studied. This was rationalized by in silico experiments.

PARA-QUINOL DERIVATIVES AND METHODS OF STEREO SELECTIVELY SYNTHESIZING AND USING SAME

This application relates to para-quinol derivatives, such as analogues of manumycins, aranorosins and gymnastatins. This application also relates to methods of synthesizing and using the para-quinol derivatives. In one embodiment of the invention a compou

HIV protease inhibitors based on amino acid derivatives

A compound selected from the group consisting of a compound of formula I 1a compound of formula II 2and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.

Total synthesis of tricyclic azaspirane derivatives of tyrosine: FR901483 and TAN1251C

A solution to the long-standing problem presented by the oxidative cyclization of a phenolic 3-arylpropionamide to a spirolactam has been developed in this laboratory via oxazoline chemistry. This research was motivated by our interest in some novel tricyclic azaspirane natural products formally derived from tyrosine, such as FR901483 and TAN1251C. In this paper, we disclose full details of the total synthesis of these substances.

Total synthesis of FR901483

The total synthesis of FR901483, a structurally novel immunosuppressant, has been accomplished by the use of technology recently developed in this laboratory for the oxidative cyclization of phenolic oxazolines to spirolactams. Our approach may reflect th

Design and synthesis of macro-heterocycles structurally related to tirofiban

Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18- or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate that the results depend a lot on the structure of the targets and on the length of the reaction sequence. (C) 2000 Published by Elsevier Science Ltd.