C₂₇H₃₂O₈

Base Information

Chemical Name:C₂₇H₃₂O₈
CAS No.:182203-22-1
Molecular Formula:C₂₇H₃₂O₈
Molecular Weight:484.546
Hs Code.:

C<sub>27</sub>H<sub>32</sub>O<sub>8</sub>

Synonyms:C₂₇H₃₂O₈

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Chemical Property of C₂₇H₃₂O₈

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Technology Process of C₂₇H₃₂O₈

There total 21 articles about C₂₇H₃₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 182203-20-9
C₂₇H₃₀O₆

: 182203-22-1
C₂₇H₃₂O₈

: C₂₇H₃₂O₈

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; osmium(VIII) oxide; In tetrahydrofuran; at -40 ℃; for 24h;
DOI:10.1016/0040-4039(96)01332-9

Reference yield:

: 22614-34-2
9α,11α-epoxy-4-androstene-3,17-dione

: 182203-22-1
C₂₇H₃₂O₈

Guidance literature:: Multi-step reaction with 18 steps

1: iPr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

2: 1) mCPBA, KHCO₃, 2) citric acid / 1) CH₂Cl₂, -30 to -20 deg C, 1 h, 2) MeOH, 0 deg C to RT

3: NaIO₄ / methanol; H₂O / 0 deg C, 12 h; RT, 3 h

4: CHCl₃ / Ambient temperature

5: 71 percent / LTBA / tetrahydrofuran / -78 to -40 deg C; -35 deg C, 4 h

6: 89 percent / nBu₃P / tetrahydrofuran / 1 h / 0 - 20 °C

7: 85 percent / 30percent H₂O₂ / tetrahydrofuran / 18 h / 0 - 20 °C

8: I₂, NaHCO₃ / CH₂Cl₂ / 48 h / Ambient temperature

9: 90 percent / methanol / 4 h / 0 - 20 °C

10: LTBA / tetrahydrofuran / 3 h / 0 °C

11: pyridine / 2 h / 0 - 20 °C

12: 56 percent / CSA, dihydroquinone / benzene / 3 h / Heating

13: 1) mCPBA, 2) 2N HCl / 1) CH₂Cl₂, -30 to -25 deg C, 20 h, 2) THF, RT, 16 h

14: Me₄NBH(OAc)3 / acetic acid; acetonitrile / 2 h / 0 °C

15: DDQ / dioxane / 4 h / 80 °C

16: 94 percent / Ag₂O / acetonitrile / 24 h / Ambient temperature

17: 92 percent / MsCl, Et₃N / CH₂Cl₂ / Ambient temperature

18: 47 percent / OsO₄, DABCO / tetrahydrofuran / 24 h / -40 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; sodium periodate; osmium(VIII) oxide; tributylphosphine; camphor-10-sulfonic acid; dihydrogen peroxide; iodine; sodium hydrogencarbonate; potassium hydrogencarbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; hydroquinone; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; citric acid; silver(l) oxide; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetic acid; acetonitrile; benzene;
DOI:10.1016/0040-4039(96)01332-9

Reference yield:

: 382-44-5
(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione

: 182203-22-1
C₂₇H₃₂O₈

Guidance literature:: Multi-step reaction with 20 steps

1: p-TsOH / benzene / 24 h / Heating

2: 80 percent / mCPBA / CH₂Cl₂ / 24 h / -20 - 0 °C

3: iPr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

4: 1) mCPBA, KHCO₃, 2) citric acid / 1) CH₂Cl₂, -30 to -20 deg C, 1 h, 2) MeOH, 0 deg C to RT

5: NaIO₄ / methanol; H₂O / 0 deg C, 12 h; RT, 3 h

6: CHCl₃ / Ambient temperature

7: 71 percent / LTBA / tetrahydrofuran / -78 to -40 deg C; -35 deg C, 4 h

8: 89 percent / nBu₃P / tetrahydrofuran / 1 h / 0 - 20 °C

9: 85 percent / 30percent H₂O₂ / tetrahydrofuran / 18 h / 0 - 20 °C

10: I₂, NaHCO₃ / CH₂Cl₂ / 48 h / Ambient temperature

11: 90 percent / methanol / 4 h / 0 - 20 °C

12: LTBA / tetrahydrofuran / 3 h / 0 °C

13: pyridine / 2 h / 0 - 20 °C

14: 56 percent / CSA, dihydroquinone / benzene / 3 h / Heating

15: 1) mCPBA, 2) 2N HCl / 1) CH₂Cl₂, -30 to -25 deg C, 20 h, 2) THF, RT, 16 h

16: Me₄NBH(OAc)3 / acetic acid; acetonitrile / 2 h / 0 °C

17: DDQ / dioxane / 4 h / 80 °C

18: 94 percent / Ag₂O / acetonitrile / 24 h / Ambient temperature

19: 92 percent / MsCl, Et₃N / CH₂Cl₂ / Ambient temperature

20: 47 percent / OsO₄, DABCO / tetrahydrofuran / 24 h / -40 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; sodium periodate; osmium(VIII) oxide; tributylphosphine; camphor-10-sulfonic acid; dihydrogen peroxide; iodine; sodium hydrogencarbonate; potassium hydrogencarbonate; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; hydroquinone; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; citric acid; silver(l) oxide; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetic acid; acetonitrile; benzene;
DOI:10.1016/0040-4039(96)01332-9