trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline

Base Information

Chemical Name:trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline
CAS No.:129540-07-4
Molecular Formula:C₁₉H₂₀BrNS
Molecular Weight:374.345
Hs Code.:

Synonyms:trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline

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Chemical Property of trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline

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Technology Process of trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline

There total 10 articles about trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6091-64-1
2-bromobenzoic acid ethyl ester

: 129540-07-4
trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH

2: 97 percent / NaBH₄

4: polyphosphoric acid

5: 1.) BH₃*THF, 2.) 25percent aq. NaOH / 2.) DMSO, reflux, 30 min

With sodium hydroxide; sodium tetrahydroborate; PPA; borane-THF; sodium hydride;
DOI:10.1021/jm00172a018

Reference yield:

: 6091-64-1
2-bromobenzoic acid ethyl ester

: 129540-07-4
cis-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH

2: 97 percent / NaBH₄

4: polyphosphoric acid

5: 1.) BH₃*THF, 2.) 25percent aq. NaOH / 2.) DMSO, reflux, 30 min

With sodium hydroxide; sodium tetrahydroborate; PPA; borane-THF; sodium hydride;
DOI:10.1021/jm00172a018

Reference yield:

: 129540-26-7
2-(2-bromophenyl)-1-pyrroline

: 129540-07-4
trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NaBH₄

3: polyphosphoric acid

4: 1.) BH₃*THF, 2.) 25percent aq. NaOH / 2.) DMSO, reflux, 30 min

With sodium hydroxide; sodium tetrahydroborate; PPA; borane-THF;
DOI:10.1021/jm00172a018