2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide

Base Information

Chemical Name:2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide
CAS No.:1204212-45-2
Molecular Formula:C₂₃H₁₃F₃N₄O₃S
Molecular Weight:482.442
Hs Code.:

Synonyms:2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide

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Chemical Property of 2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide

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Technology Process of 2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide

There total 3 articles about 2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204213-00-2
4-(2-phenyl-6-trifluoromethoxy-4-quinolinecarbonyl)-1-(2-thiophenecarbonyl)thiosemicarbazide

: 1204212-45-2
2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide

Guidance literature:: With pyridine; p-toluenesulfonyl chloride; at 20 ℃;

Reference yield:

: 169037-23-4
5-trifluoromethoxy-1H-indole-2,3-dione

: 1204212-45-2
2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol / 1 h / Cooling with ice; Reflux

2.1: oxalyl dichloride / dichloromethane / 3 h / 20 °C

2.2: 1 h / 20 °C

2.3: 20 °C

3.1: pyridine; p-toluenesulfonyl chloride / 20 °C

With pyridine; oxalyl dichloride; p-toluenesulfonyl chloride; potassium hydroxide; In ethanol; dichloromethane;

Reference yield:

: 897564-36-2
2-phenyl-6-trifluoromethoxyquinoline-4-carboxylic acid

: 1204212-45-2
2-phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl]-6-trifluoromethoxy-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane / 3 h / 20 °C

1.2: 1 h / 20 °C

1.3: 20 °C

2.1: pyridine; p-toluenesulfonyl chloride / 20 °C

With pyridine; oxalyl dichloride; p-toluenesulfonyl chloride; In dichloromethane;