4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride

Base Information

Chemical Name:4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride
CAS No.:1300737-63-6
Molecular Formula:C₂₆H₂₇N₃O₄*ClH
Molecular Weight:481.979
Hs Code.:

Synonyms:4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride

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Chemical Property of 4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride

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Technology Process of 4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride

There total 7 articles about 4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1300737-57-8
Ethyl 4-{[2-(1,1-di methylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylate

: 1300737-63-6
4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride

Guidance literature:: Ethyl 4-{[2-(1,1-di methylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylate; With ethanol; sodium hydroxide; for 24h; Reflux;

With hydrogenchloride; In water;

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1300737-63-6
4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: barium hydroxide octahydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 80 °C

2: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 24 h

3: 1 h / 130 °C

4: diphenylether / 0.75 h / 255 °C

5: trichlorophosphate / Reflux

6: 1,4-dioxane / 48 h / Reflux

7: ethanol; sodium hydroxide / 24 h / Reflux

With barium hydroxide octahydrate; ethanol; hydrogen; acetic acid; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; diphenylether; ethanol; water; 1: Suzuki Coupling;

Reference yield:

: 5399-03-1
2-iodo-1-methoxy-4-nitrobenzene

: 1300737-63-6
4-{[2-(1,1-dimethylethyl)phenyl]amino}-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: barium hydroxide octahydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 80 °C

2: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 24 h

3: 1 h / 130 °C

4: diphenylether / 0.75 h / 255 °C

5: trichlorophosphate / Reflux

6: 1,4-dioxane / 48 h / Reflux

7: ethanol; sodium hydroxide / 24 h / Reflux

With barium hydroxide octahydrate; ethanol; hydrogen; acetic acid; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; diphenylether; ethanol; water; 1: Suzuki Coupling;