[3-(3,5-diMethyl-4-isoxazolyl)-4-(Methyloxy)phenyl]aMine

Base Information

Chemical Name:[3-(3,5-diMethyl-4-isoxazolyl)-4-(Methyloxy)phenyl]aMine
CAS No.:1300031-61-1
Molecular Formula:C12H14N2O2
Molecular Weight:218.255
Hs Code.:
Mol file:1300031-61-1.mol

Synonyms:[3-(3,5-diMethyl-4-isoxazolyl)-4-(Methyloxy)phenyl]aMine;3-(3,5-dimethylisoxazol-4-yl)-4-methoxyaniline

Suppliers and Price of [3-(3,5-diMethyl-4-isoxazolyl)-4-(Methyloxy)phenyl]aMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of [3-(3,5-diMethyl-4-isoxazolyl)-4-(Methyloxy)phenyl]aMine

Chemical Property:

Boiling Point:343.3±42.0 °C(Predicted)
PKA:4.55±0.10(Predicted)
PSA：61.28000
Density:1.151±0.06 g/cm3(Predicted)
LogP:3.13040

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of [3-(3,5-diMethyl-4-isoxazolyl)-4-(Methyloxy)phenyl]aMine

There total 5 articles about [3-(3,5-diMethyl-4-isoxazolyl)-4-(Methyloxy)phenyl]aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1300031-62-2
3,5-dimethyl-4-[2-(methyloxy)-5-nitrophenyl]isoxazole

: 1300031-61-1
[3-(3,5-dimethyl-4-isoxazolyl)-4-(methyloxy)phenyl]amine

Guidance literature:: With palladium on activated charcoal; hydrogen; sodium sulfite; In ethanol; ethyl acetate; for 24h;
DOI:10.1016/j.bmcl.2012.01.125

Reference yield: 93.0%

: 832114-00-8
3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole

: 74587-12-5
3-iodo-4-methoxyaniline

: 1300031-61-1
[3-(3,5-dimethyl-4-isoxazolyl)-4-(methyloxy)phenyl]amine

Guidance literature:: With palladium diacetate; caesium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1300031-61-1
[3-(3,5-dimethyl-4-isoxazolyl)-4-(methyloxy)phenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen; sodium sulfite / ethanol; ethyl acetate / 24 h

With palladium on activated charcoal; hydrogen; caesium carbonate; sodium sulfite; In 1,2-dimethoxyethane; ethanol; water; ethyl acetate; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.125