methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate

Base Information

• Chemical Name: methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate
• CAS No.: 226082-54-8
• Molecular Formula: C₃₀H₄₂O₄SeSi
• Molecular Weight: 573.707

Synonyms:methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate

Chemical Property of methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate

There total 3 articles about methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butylchlorosilane (56310-18-0) + methyl (+/-)-5-hydroxy-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate (226082-53-7) → methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate (226082-54-8)

Guidance literature:

With 1H-imidazole; In tetrahydrofuran; for 12h; Heating;

DOI:10.1021/jo982225m

Reference yield:

phenylselanyl-acetic acid methyl ester (68872-84-4) → methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate (226082-54-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) C₆H₁₁NLiPr-i / 1.) THF, -78 deg C (30 min), -> room temperature (40 min), 2.) THF, DMSO, room temperature, 3 h

2: aq. TFA / CH₂Cl₂ / 14 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexanes, -78 deg C, 15 min, 2.) THF, hexanes, -78 deg C, 2 h

4: 95 percent / imidazole / tetrahydrofuran / 12 h / Heating

With 1H-imidazole; n-butyllithium; C₆H₁₁NLiPr-i; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo982225m

Reference yield:

methyl 5-formyl-2-(phenylseleno)pentanoate (226082-51-5) → methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate (226082-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexanes, -78 deg C, 15 min, 2.) THF, hexanes, -78 deg C, 2 h

2: 95 percent / imidazole / tetrahydrofuran / 12 h / Heating

With 1H-imidazole; n-butyllithium; In tetrahydrofuran;

DOI:10.1021/jo982225m

upstream raw materials:

di-tert-butylchlorosilane

methyl (+/-)-5-hydroxy-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate

phenylselanyl-acetic acid methyl ester

methyl 5-formyl-2-(phenylseleno)pentanoate

Downstream raw materials:

(3aα,4α,6aα)-(+/-)-hexahydro-4-(hydroxymethyl)cyclopentafuran-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 226082-54-8 methyl (+/-)-5-<oxy>-8-(phenylmethoxy)-2-(phenylseleno)-6-octynoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send