(5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone

Base Information

• Chemical Name: (5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone
• CAS No.: 1027476-73-8
• Molecular Formula: C₂₀H₁₉NO₅
• Molecular Weight: 353.375
• Mol file: 1027476-73-8.mol

Synonyms:(5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone

Chemical Property of (5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone

There total 16 articles about (5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C20H21NO6 (1075231-78-5) → (5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone (1027476-73-8)

Guidance literature:

With boron trifluoride diethyl etherate; In benzene; at 20 ℃; for 12h;

DOI:10.1080/00397910802116575

Reference yield: 73.0%

(6-bromo-2,3-dimethoxy-phenyl)-(5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-methanone (385390-30-7) → lennoxamine (38542-77-7,95530-38-4) + (5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone (1027476-73-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 8h; Inert atmosphere; Reflux;

DOI:10.1021/jo900311g

Reference yield:

C20H18BrNO6 (945594-74-1) → (5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone (1027476-73-8)

Guidance literature:

Multi-step reaction with 3 steps

1: KHMDS; HMPA / tetrahydrofuran / -78 °C

2: Me₂PhSiH / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 80 °C

3: 25 percent / n-Bu₃SnH; AIBN / benzene / 105 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2'-azobis(isobutyronitrile); Dimethylphenylsilane; tri-n-butyl-tin hydride; potassium hexamethylsilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;

DOI:10.1039/b706087d

upstream raw materials:

(6-bromo-2,3-dimethoxy-phenyl)-(5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-methanone

C₂₀H₁₈BrNO₆

C₃₂H₂₇BrNO₉P

1,3-benzodioxole-5-acetic acid