Ethyl 5-((tert-butoxycarbonyl)amino)pyrazolo[1,5-a]pyridine-3-carboxylate

Base Information

• Chemical Name: Ethyl 5-((tert-butoxycarbonyl)amino)pyrazolo[1,5-a]pyridine-3-carboxylate
• CAS No.: 1101120-33-5
• Molecular Formula: C15H19N3O4
• Molecular Weight: 305.334
• Hs Code.: 2933990090
• Mol file: 1101120-33-5.mol

Synonyms:ethyl 5-[(2-methylpropan-2-yl)oxycarbonylamino]pyrazolo[1,5-a]pyridine-3-carboxylate;

Chemical Property of Ethyl 5-((tert-butoxycarbonyl)amino)pyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property:

• PKA: 8.19±0.46(Predicted)
• PSA: 85.42000
• Density: 1.23
• LogP: 2.87160
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl5-((tert-Butoxycarbonyl)amino)pyrazolo[1,5-a]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 5-((tert-Butoxycarbonyl)amino)pyrazolo[1,5-a]pyridine-3-carboxylate is a useful reactant in organic synthesis.

Technology Process of Ethyl 5-((tert-butoxycarbonyl)amino)pyrazolo[1,5-a]pyridine-3-carboxylate

There total 9 articles about Ethyl 5-((tert-butoxycarbonyl)amino)pyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

N-(4-pyridyl) t-butyl carbamate (98400-69-2) + propynoic acid ethyl ester (623-47-2) → 5-[(tert-butoxycarbonyl)amino]pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (1101120-33-5)

Guidance literature:

N-(4-pyridyl) t-butyl carbamate; With O-(2,4-dinitrophenyl)hydroxylamine; In acetonitrile; at 40 ℃; for 18h;

propynoic acid ethyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2011.11.029

Reference yield: 36.0%

→ 5-[(tert-butoxycarbonyl)amino]pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (1101120-33-5)

Guidance literature:

Reference yield:

ethyl 3-(trimethylsilyl)propynoate (16205-84-8) + tert-butyl N-(1-aminopyridin-1-ium-4-yl)carbamate 2,4-dinitrophenolate (1394839-06-5) → 5-[(tert-butoxycarbonyl)amino]pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (1101120-33-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 15 - 25 ℃; for 4.16667h;

upstream raw materials:

N-(4-pyridyl) t-butyl carbamate

propynoic acid ethyl ester

ethyl 3-(trimethylsilyl)propynoate

tert-butyl N-(1-aminopyridin-1-ium-4-yl)carbamate 2,4-dinitrophenolate

Downstream raw materials:

5-bromopyrazolo[1,5-a]pyridine

pyrazolo[1,5-a]pyridin-5-amine

5-chloropyrazolo[1,5-a]pyridine

5-bromopyrazolo[1,5-a]pyridine-3-carbaldehyde