N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide

Base Information

• Chemical Name: N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide
• CAS No.: 1220510-41-7
• Molecular Formula: C₂₃H₂₈FN₅O₆
• Molecular Weight: 489.504

Synonyms:N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide

Chemical Property of N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide

Chemical Property:

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Technology Process of N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide

There total 3 articles about N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,N-dimethyloxamic acid (32833-96-8) + C10H16O4*2C25H27FN4O6S → N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide (1220510-41-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 30 ℃; pH=6.8; Industry scale; Potassium phosphate buffer;

Reference yield:

N,N-dimethyloxamic acid (32833-96-8) + (6S,10S)-N-(4-fluoro-3-methylbenzyl)-3-hydroxy-6-methyl-10-(methylamino)-4-oxo-6,7,9,10-tetrahydro-4-pyrimido[1,2-a][1,4]oxazepine-2-carboxamide hydrochloride → N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide (1220510-41-7)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 18h;

Reference yield:

N,N-dimethyloxamic acid (32833-96-8) + (6S)-N-(4-fluoro-3-methylbenzyl)-3-hydroxy-6-methyl-10-(methylamino)-4-oxo-6,7,9,10-tetrahydro-4-pyrimido[1,2-a][1,4]oxazepine-2-carboxamide hydrochloride → N-((6S,10R)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide (1220510-42-8) + N-((6S,10S)-2-{[(4-fluoro-3-methylbenzyl)amino]carbonyl}-3-hydroxy-6-methyl-4-oxo-6,7,9,10-tetrahydro-4H-pyrimido[1,2-d][1,4]oxazepin-10-yl)-N,N',N'-trimethylethanediamide (1220510-41-7)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 - 25 ℃; for 18h;

upstream raw materials:

N,N-dimethyloxamic acid

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