N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine

Base Information

Chemical Name:N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine
CAS No.:383653-71-2
Molecular Formula:C₃₀H₃₉ClN₂O₈
Molecular Weight:591.101
Hs Code.:

Synonyms:N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine

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Technology Process of N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine

There total 9 articles about N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 383661-79-8
methyl N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine

: 383653-71-2
N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃; for 0.5h;
DOI:10.1021/jm020234o

Reference yield:

: 383653-04-1
(3R,5S)-N-propanesulfonyl-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetamide

: N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethoxypropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine methyl ester

: 383653-71-2
N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine

Guidance literature:: With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

: 597-31-9
2,2-dimethyl-3-hydroxypropionaldehyde

: 383653-71-2
N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]-D-leucine

Guidance literature:: Multi-step reaction with 7 steps

1: AcOH / methanol / 1 h / 60 °C

2: NaBH₃CN / methanol / 2 h / 60 °C

3: 100 percent / NaHCO₃ / ethyl acetate / 0.5 h / 20 °C

4: 79 percent / K₂CO₃ / ethanol / 20 °C

5: 94 percent / aq. NaOH / ethanol / 2 h / 60 °C

6: 100 percent / diethylphosphoryl cyanide; Et₃N / dimethylformamide / 0.5 h / 20 °C

7: 94 percent / 1N aq. NaOH / ethanol / 0.5 h / 60 °C

With sodium hydroxide; diethylphosphoryl cyanide; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; In methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020234o