GNE-614

Base Information

Chemical Name:GNE-614
CAS No.:1189812-14-3
Molecular Formula:C₂₅H₂₄ClN₃O₄S
Molecular Weight:498.002
Hs Code.:

Synonyms:GNE-614

Suppliers and Price of GNE-614

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of GNE-614

Chemical Property:

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Technology Process of GNE-614

There total 14 articles about GNE-614 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1189816-49-6
2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylic acid

: 593-51-1
methylamine hydrochloride

: 1189812-14-3
GNE-614

Guidance literature:: methylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylic acid; With HATU; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 157245-84-6
ethyl 4-(3-bromophenoxy)butanoate

: 1189812-14-3
GNE-614

Guidance literature:: Multi-step reaction with 11 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 48 h / 50 °C

2.1: polyphosphoric acid; celite / toluene / 5 h / 110 °C

3.1: N,N-dimethyl-formamide / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

5.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 50 °C

6.1: thionyl chloride / 2 h / 80 °C

7.1: pyridine / tetrahydrofuran / 0 - 20 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

9.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 48 h / 70 °C / 2585.81 Torr

10.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C

11.2: 2 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; lithium hydroxide monohydrate; water; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2007084

Reference yield:

: 1189815-76-6
methyl 8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylate

: 1189812-14-3
GNE-614

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 50 °C

2.1: thionyl chloride / 2 h / 80 °C

3.1: pyridine / tetrahydrofuran / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 48 h / 70 °C / 2585.81 Torr

6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C

7.2: 2 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; lithium hydroxide monohydrate; water; palladium diacetate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm2007084