dimethyl 2,2'-[6-(4-sulfamoylbenzylamino)-1,3,5-triazine-2,4-diyl]bis(azanediyl)diacetate

Base Information

• Chemical Name: dimethyl 2,2'-[6-(4-sulfamoylbenzylamino)-1,3,5-triazine-2,4-diyl]bis(azanediyl)diacetate
• CAS No.: 1311200-28-8
• Molecular Formula: C₁₆H₂₁N₇O₆S
• Molecular Weight: 439.452
• Mol file: 1311200-28-8.mol

Synonyms:dimethyl 2,2'-[6-(4-sulfamoylbenzylamino)-1,3,5-triazine-2,4-diyl]bis(azanediyl)diacetate

Chemical Property of dimethyl 2,2'-[6-(4-sulfamoylbenzylamino)-1,3,5-triazine-2,4-diyl]bis(azanediyl)diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2,2'-[6-(4-sulfamoylbenzylamino)-1,3,5-triazine-2,4-diyl]bis(azanediyl)diacetate

There total 2 articles about dimethyl 2,2'-[6-(4-sulfamoylbenzylamino)-1,3,5-triazine-2,4-diyl]bis(azanediyl)diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 4-{[(4,6-dichloro-1,3,5-triazin-2-yl)amino]methyl}-benzene-1-sulfonamide (796871-26-6) → dimethyl 2,2'-[6-(4-sulfamoylbenzylamino)-1,3,5-triazine-2,4-diyl]bis(azanediyl)diacetate (1311200-28-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.04.005

Reference yield:

mafenide hydrochloride (138-37-4) → dimethyl 2,2'-[6-(4-sulfamoylbenzylamino)-1,3,5-triazine-2,4-diyl]bis(azanediyl)diacetate (1311200-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetone / 0 °C

1.2: 1.33 h

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmc.2011.04.005

upstream raw materials:

glycine ethyl ester hydrochloride

4-{[(4,6-dichloro-1,3,5-triazin-2-yl)amino]methyl}-benzene-1-sulfonamide

mafenide hydrochloride