2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

Base Information

• Chemical Name: 2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine
• CAS No.: 1314535-09-5
• Molecular Formula: C₂₃H₂₂F₃N₃O
• Molecular Weight: 413.442

Synonyms:2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

Chemical Property of 2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

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Technology Process of 2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

There total 3 articles about 2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

2-N-hexyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one (1314534-93-4) + propargyl bromide (106-96-7) → 2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine (1314535-09-5) + 2-n-hexyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)-one (1314534-99-0)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 60 ℃; regioselective reaction;

DOI:10.1016/j.ejmech.2011.05.011

Reference yield:

oenanthic acid (111-14-8) → 2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine (1314535-09-5) + 2-n-hexyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)-one (1314534-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 120 - 130 °C

2: potassium carbonate; potassium iodide / acetone / 60 °C

With sulfuric acid; potassium carbonate; potassium iodide; In acetone;

DOI:10.1016/j.ejmech.2011.05.011

Reference yield:

2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine (114085-00-6) → 2-n-hexyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine (1314535-09-5) + 2-n-hexyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)-one (1314534-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 120 - 130 °C

2: potassium carbonate; potassium iodide / acetone / 60 °C

With sulfuric acid; potassium carbonate; potassium iodide; In acetone;

DOI:10.1016/j.ejmech.2011.05.011

upstream raw materials:

2-N-hexyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

propargyl bromide

oenanthic acid

2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine

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