2-Amino-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile

Base Information

Chemical Name:2-Amino-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile
CAS No.:114085-00-6
Molecular Formula:C13H8F3N3
Molecular Weight:263.222
Hs Code.:
DSSTox Substance ID:DTXSID70550441
Nikkaji Number:J2.125.363D
Wikidata:Q82429804
Mol file:114085-00-6.mol

Synonyms:114085-00-6;2-Amino-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile;DTXSID70550441;DJVUVOFHXAZICJ-UHFFFAOYSA-N;MFCD00991983;2-amino-4-trifluoromethyl-6-phenyl-3-cyanopyridine;2-Amino-6-phenyl-4-(trifluoromethyl)nicotinonitrile

Suppliers and Price of 2-Amino-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-Amino-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:263.06703175
Heavy Atom Count:19
Complexity:354

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NC(=C(C(=C2)C(F)(F)F)C#N)N

Technology Process of 2-Amino-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile

There total 4 articles about 2-Amino-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 114085-01-7
2-azido-4-trifluoromethyl-6-phenyl-3-cyanopyridine

: 114085-00-6
2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine

Guidance literature:: With sodium sulfide; water; for 0.5h; Reflux;
DOI:10.1039/c8ob03171a

Reference yield: 83.6%

: 155635-57-7
2-((3-cyano-6-phenyl-4-(trifluoromethyl)pyridin-2-yl)oxy)acetamide

: 114085-00-6
2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 - 120 ℃; for 2h;
DOI:10.1016/0022-1139(93)02936-9

Reference yield:

: 3335-44-2
2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 114085-00-6
2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 86.4 percent / K₂CO₃, NaI / acetone / 6 h / 60 °C

2: 83.6 percent / K₂CO₃ / dimethylformamide / 2 h / 110 - 120 °C

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/0022-1139(93)02936-9