(1S)-(-)-3-OXOCAMPHORSULFONYLIMINE 98+%

Base Information

• Chemical Name: (1S)-(-)-3-OXOCAMPHORSULFONYLIMINE 98+%
• CAS No.: 119106-38-6
• Molecular Formula: C10H13 N O3 S
• Molecular Weight: 227.284
• Mol file: 119106-38-6.mol

Synonyms:3H-3a,6-Methano-2,1-benzisothiazol-7(4H)-one,5,6-dihydro-8,8-dimethyl-, 2,2-dioxide, (3aS)-

Chemical Property of (1S)-(-)-3-OXOCAMPHORSULFONYLIMINE 98+%

Chemical Property:

• PSA: 71.95000
• LogP: 1.29250

Purity/Quality:

(1S)-(-)-3-Oxocamphorsulfonylimine forsynthesis ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S)-(-)-3-OXOCAMPHORSULFONYLIMINE 98+%

There total 2 articles about (1S)-(-)-3-OXOCAMPHORSULFONYLIMINE 98+% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(1S)-(-)-camphorsulfonylimine (60886-80-8) → (3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide (119106-38-6)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 336h; Heating;

Reference yield:

(1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) → (3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide (119106-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride

1.2: Heating

2.1: acetic acid; selenium(IV) oxide / Heating

With selenium(IV) oxide; thionyl chloride; acetic acid;

DOI:10.3762/bjoc.13.122

Reference yield: 61.7%

(3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide (119106-38-6) + phenethylamine (64-04-0) → (3aS,6S)-8,8-dimethyl-7-(2-phenylethyl)imino-4,5,6,7-tetrahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

Guidance literature:

With titanium tetrachloride; In toluene; at 0 ℃; for 16h; Reflux;

DOI:10.3762/bjoc.13.122

upstream raw materials:

(1S)-(-)-camphorsulfonylimine

(1S)-10-camphorsulfonic acid

Downstream raw materials:

(1S,5S,6S,7S)-10,10-Dimethyl-3,3-dioxo-5,6-bis-phenylethynyl-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decan-6-ol

(1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

(1S,5S,6S,7S)-4,10,10-Trimethyl-3,3-dioxo-5,6-bis-phenylethynyl-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decan-6-ol

(1S,5S,6S,7S)-6-Methoxy-4,10,10-trimethyl-5,6-bis-phenylethynyl-3-thia-4-aza-tricyclo[5.2.1.0^1,5]decane 3,3-dioxide