(1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

Base Information

• Chemical Name: (1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide
• CAS No.: 479206-75-2
• Molecular Formula: C₂₈H₂₉NO₃S
• Molecular Weight: 459.609
• Mol file: 479206-75-2.mol

Synonyms:

Chemical Property of (1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

There total 3 articles about (1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

propargyl benzene (10147-11-2) + (3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide (119106-38-6) → (3aS,7R)-7-hydroxy-8,8-dimethyl-7-(3-phenyl-1-propynyl)-4,5,6,7-tetrahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide + (1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (479206-75-2)

Guidance literature:

propargyl benzene; With n-butyllithium; In diethyl ether; hexane; for 18h;

(3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide; In diethyl ether; hexane; for 46h;

DOI:10.1515/znb-2002-0616

Reference yield: 20.0%

propargyl benzene (10147-11-2) + (3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide (119106-38-6) → (1aS,3aS)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-7-oxo-1a-(3-phenylpropadienyl)-2,1-benzisothiazole 2,2-dioxide + (3aS,7R)-7-hydroxy-8,8-dimethyl-7-(3-phenyl-1-propynyl)-4,5,6,7-tetrahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide + (1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (479206-75-2)

Guidance literature:

propargyl benzene; With n-butyllithium; In diethyl ether; hexane;

(3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide; In diethyl ether; hexane;

DOI:10.1515/znb-2002-0616

Reference yield:

propargyl benzene (10147-11-2) + (3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide (119106-38-6) → (1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8-dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (479206-75-2)

Guidance literature:

With n-butyllithium; Inert atmosphere; Schlenk technique;

DOI:10.1080/00397911.2012.702290

upstream raw materials:

propargyl benzene

(3aS)-8,8-dimethyl-5,6-dihydro-3H-3a,6-methano-2,1-benzoisothiazol-7(4H)-one 2,2-dioxide

Downstream raw materials:

(2S,3aS,6S)-9-benzyl-5,6-dihydro-11,11-dimethyl-10-phenylacetyl-3H-3a,6-methano-1H-cyclonon[c]isothiazol-7(4H)-one 2-oxide