Ethyl 1-azabicyclo[2.2.1]heptane-4-carboxylate

Base Information

Chemical Name:Ethyl 1-azabicyclo[2.2.1]heptane-4-carboxylate
CAS No.:119102-24-8
Molecular Formula:C9H15 N O2
Molecular Weight:169.224
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10576504
Wikidata:Q82466237
Mol file:119102-24-8.mol

Synonyms:ethyl 1-azabicyclo[2.2.1]heptane-4-carboxylate;119102-24-8;Ethyl1-azabicyclo[2.2.1]heptane-4-carboxylate;SCHEMBL592258;DTXSID10576504;CPHZSWAWMNOQJI-UHFFFAOYSA-N;1-AZABICYCLO[2.2.1]HEPTANE-4-CARBOXYLIC ACID, ETHYL ESTER;AKOS006286964;MB06037;CS-0442131;F89234;Ethyl 1-azabicyclo[2.2.1]hept-4-ylcarboxylate;Ethyl-1-azabicyclo[2.2.1]hept-4-ylcarboxylate;ethyl 1-azabicyclo[2.2.1 ]heptane-4-carboxylate;1-azabicyclo[2.2.1]heptane-4-carboxylic acid ethyl ester

Suppliers and Price of Ethyl 1-azabicyclo[2.2.1]heptane-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl1-Azabicyclo[2.2.1]heptane-4-carboxylate
10mg
$ 65.00

American Custom Chemicals Corporation
ETHYL-1-AZABICYCLO-[2.2.1]-HEPTANE-4-CARBOXYLATE 95.00%
5MG
$ 499.65

AccelPharmtech
1-Azabicyclo[2.2.1]heptane-4-carboxylicacid,ethylester 97.00%
25G
$ 7320.00

AccelPharmtech
1-Azabicyclo[2.2.1]heptane-4-carboxylicacid,ethylester 97.00%
5G
$ 3900.00

AccelPharmtech
1-Azabicyclo[2.2.1]heptane-4-carboxylicacid,ethylester 97.00%
1G
$ 2280.00

Total 8 raw suppliers

Chemical Property of Ethyl 1-azabicyclo[2.2.1]heptane-4-carboxylate

Chemical Property:

PSA：29.54000
LogP:0.58320
XLogP3:0.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:169.110278721
Heavy Atom Count:12
Complexity:195

Purity/Quality:

97% ^*data from raw suppliers

Ethyl1-Azabicyclo[2.2.1]heptane-4-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C12CCN(C1)CC2

Technology Process of Ethyl 1-azabicyclo[2.2.1]heptane-4-carboxylate

There total 4 articles about Ethyl 1-azabicyclo[2.2.1]heptane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119102-91-9
1-Benzyl-4-ethoxycarbonyl-1-azonia-bicyclo[2.2.1]heptane; bromide

: 119102-24-8
ethyl 1-azabicyclo<2.2.1>hept-4-yl carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 40 ℃; under 760 Torr;
DOI:10.1021/jm00113a009

Reference yield:

: 17012-21-4
1-benzylpyrrolidine-3-carboxylic acid methyl ester

: 119102-24-8
ethyl 1-azabicyclo<2.2.1>hept-4-yl carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA, N,N,N¹,N¹-tetramethylethylenediamine (TMEDA) / 1.) Et₂O, hexane, -65 deg C, 0.25 h, 2.) Et₂O, hexane, a) from -65 deg C to RT, 2 h, b) reflux, 30 min

2: HBr (gas) / 84 h / Ambient temperature

3: aq. K₂CO₃ / 0.17 h

4: H₂ / 10percent Pd/C / ethanol / 40 °C / 760 Torr

With N,N,N,N,-tetramethylethylenediamine; hydrogen bromide; hydrogen; potassium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00113a009

Reference yield:

: 119102-90-8
7-benzyl-7-aza-2-oxaspiro<4.4>nonan-1-one

: 119102-24-8
ethyl 1-azabicyclo<2.2.1>hept-4-yl carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: HBr (gas) / 84 h / Ambient temperature

2: aq. K₂CO₃ / 0.17 h

3: H₂ / 10percent Pd/C / ethanol / 40 °C / 760 Torr

With hydrogen bromide; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00113a009