(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

Base Information

Chemical Name:(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide
CAS No.:500767-23-7
Molecular Formula:C₃₂H₃₉N₃O₆
Molecular Weight:561.678
Hs Code.:

Synonyms:(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

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Chemical Property of (2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

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Technology Process of (2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

There total 3 articles about (2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 500767-16-8
(2R,5S,6S)-3-aza-2-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

: 500767-23-7
(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: With sodium carbonate; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm020951i

Reference yield:

: 5241-58-7,5241-59-8,17193-31-6,60058-39-1
D-Phenylalaninamide

: 500767-23-7
(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / propan-2-ol / Heating

2: 73 percent / aq. Na₂CO₃ / tetrahydrofuran / 20 °C

With sodium carbonate; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm020951i

Reference yield:

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 500767-23-7
(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / propan-2-ol / Heating

2: 73 percent / aq. Na₂CO₃ / tetrahydrofuran / 20 °C

With sodium carbonate; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm020951i