{[2-(Methoxymethoxy)phenyl]ethynyl}(trimethyl)silane

Base Information

• Chemical Name: {[2-(Methoxymethoxy)phenyl]ethynyl}(trimethyl)silane
• CAS No.: 939794-47-5
• Molecular Formula: C₁₃H₁₈O₂Si
• Molecular Weight: 234.37
• DSSTox Substance ID: DTXSID20705005
• Wikidata: Q82637636
• Mol file: 939794-47-5.mol

Synonyms:SCHEMBL2289638;DTXSID20705005;939794-47-5;{[2-(Methoxymethoxy)phenyl]ethynyl}(trimethyl)silane

Chemical Property of {[2-(Methoxymethoxy)phenyl]ethynyl}(trimethyl)silane

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 234.107606347
• Heavy Atom Count: 16
• Complexity: 269

Purity/Quality:

99%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COCOC1=CC=CC=C1C#C[Si](C)(C)C

Technology Process of {[2-(Methoxymethoxy)phenyl]ethynyl}(trimethyl)silane

There total 1 articles about {[2-(Methoxymethoxy)phenyl]ethynyl}(trimethyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-iodo-2-methoxymethoxybenzene (80778-47-8) + trimethylsilylacetylene (1066-54-2) → ((2-(methoxymethoxy)phenyl)ethynyl)trimethylsilane (939794-47-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 50 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1021/ol9001174

Reference yield: 100.0%

((2-(methoxymethoxy)phenyl)ethynyl)trimethylsilane (939794-47-5) → 1-ethynyl-2-(methoxymethoxy)benzene (634153-24-5)

Guidance literature:

With potassium fluoride; In methanol; at 20 ℃; for 3h;

Reference yield:

((2-(methoxymethoxy)phenyl)ethynyl)trimethylsilane (939794-47-5) → N-((2-(methoxymethoxy)phenyl)ethynyl)-N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)benzenesulfonamide

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; methanol / 1 h / 20 °C

2: silver nitrate; N-Bromosuccinimide / acetone / 1 h / 20 °C

3: copper(I) bromide; N,N`-dimethylethylenediamine; potassium phosphate / toluene / 12 h / 80 °C

With methanol; potassium phosphate; N-Bromosuccinimide; potassium carbonate; silver nitrate; copper(I) bromide; N,N`-dimethylethylenediamine; In acetone; toluene;

DOI:10.1002/anie.202115554

upstream raw materials:

1-iodo-2-methoxymethoxybenzene

trimethylsilylacetylene

Downstream raw materials:

1-ethynyl-2-(methoxymethoxy)benzene

ethyl 4-((2-hydroxyphenyl)ethynyl)benzoate

2-(thiophen-2-ylethynyl)phenol

ethyl 4-((2-(methoxymethoxy)phenyl)ethynyl)benzoate