(3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid

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Chemical Name:(3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid
CAS No.:230961-71-4
Molecular Formula:C₃₃H₃₉ClN₂O₄
Molecular Weight:563.137
Hs Code.:

Synonyms:(3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid

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Chemical Property of (3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid

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Technology Process of (3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid

There total 10 articles about (3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 230962-05-7
tert-butyl (3R)-6-[(3-chloro-4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoate

: 230961-71-4
(3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 3.25h;

Reference yield:

: 179533-97-2
(R)-2-(2-(tert-butoxy)-2-oxoethyl)pent-4-enoic acid

: 230961-71-4
(3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N'-dimethylaminopropylcarbodiimide; 7-aza-1-hydroxy-1,2,3-benzotriazole; N-methylmorpholine / CH₂Cl₂ / 18 h / 0 - 20 °C

2: 5 mol percent Pd(OAc)2*2P(o-tol)3; Et₃N / dimethylformamide / 100 °C

3: 74 percent / TsNHNH₂ / toluene / 4 h / Heating

4: HCl gas / CH₂Cl₂ / 0 °C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; Pd(OAc)2[P(2-tolyl)3]2; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; toluene-4-sulfonic acid hydrazide; In dichloromethane; N,N-dimethyl-formamide; toluene; 2: Heck reaction;
DOI:10.1016/S0960-894X(00)00720-4

Reference yield:

: 230961-69-0
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

: 230961-71-4
(3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 5 mol percent Pd(OAc)2*2P(o-tol)3; Et₃N / dimethylformamide / 100 °C

2: 74 percent / TsNHNH₂ / toluene / 4 h / Heating

3: HCl gas / CH₂Cl₂ / 0 °C

With hydrogenchloride; Pd(OAc)2[P(2-tolyl)3]2; triethylamine; toluene-4-sulfonic acid hydrazide; In dichloromethane; N,N-dimethyl-formamide; toluene; 1: Heck reaction;
DOI:10.1016/S0960-894X(00)00720-4