4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

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Chemical Name:4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid
CAS No.:879880-73-6
Molecular Formula:C₄₈H₅₄N₆O₉S
Molecular Weight:891.058
Hs Code.:

4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Synonyms:4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

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Chemical Property of 4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

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Technology Process of 4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

There total 6 articles about 4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 879880-72-5
4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid tert-butyl ester

: 879880-73-6
4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1002/chem.200500876

Reference yield:

: N-[1-(2-Amino-ethylamino)-1-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-2-phenyl-ethylamino]-ethylamino}-meth-(Z)-ylidene]-4-methyl-benzenesulfonamide

: 879880-73-6
4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 510 mg / EDC; HOBt; DIPEA / CH₂Cl₂ / 36 h / 20 °C

2: 86 percent / trifluoroacetic acid / CH₂Cl₂ / 18 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/chem.200500876

Reference yield:

: 879880-71-4
(2-{[{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-2-phenyl-ethylamino]-ethylamino}-(toluene-4-sulfonylimino)-methyl]-amino}-ethyl)-carbamic acid tert-butyl ester

: 879880-73-6
4-{2-{{{2-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-phenylethylamino]ethylamino}(toluene-4-sulfonylimino)methyl}amino}ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

2: 510 mg / EDC; HOBt; DIPEA / CH₂Cl₂ / 36 h / 20 °C

3: 86 percent / trifluoroacetic acid / CH₂Cl₂ / 18 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/chem.200500876