Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester

Base Information

Chemical Name:Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester
CAS No.:192461-35-1
Molecular Formula:C₃₅H₃₁N₃O₆
Molecular Weight:589.648
Hs Code.:

Synonyms:Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester

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Chemical Property of Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester

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Technology Process of Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester

There total 3 articles about Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3739-94-4
2,6-Pyridinedicarbonyl dichloride

: 207735-28-2
(6-((benzyloxy)methyl)pyridin-2-yl)methanol

: 192461-35-1
Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester

Guidance literature:: With dmap; In dichloromethane; 1.) 0 deg C, 10 min, 2.) room temperature, 30 min;
DOI:10.1021/jo9721148

Reference yield:

: 155269-58-2
2,6-bis(hydroxymethyl)pyridine monotrityl ether

: 192461-35-1
Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, THF, 0 deg C, 30 min, 2.) room temperature, 12 h

2: 96 percent / conc. HCl / methanol; CH₂Cl₂ / 0.33 h / Ambient temperature

3: 72 percent / DMAP / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) room temperature, 30 min

With hydrogenchloride; dmap; sodium hydride; In methanol; dichloromethane;
DOI:10.1021/jo9721148

Reference yield:

: 207735-34-0
2-Benzyloxymethyl-6-trityloxymethyl-pyridine

: 192461-35-1
Pyridine-2,6-dicarboxylic acid bis-(6-benzyloxymethyl-pyridin-2-ylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / conc. HCl / methanol; CH₂Cl₂ / 0.33 h / Ambient temperature

2: 72 percent / DMAP / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) room temperature, 30 min

With hydrogenchloride; dmap; In methanol; dichloromethane;
DOI:10.1021/jo9721148