Technology Process of (S)-2-Chloromethyl-3-methyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
There total 3 articles about (S)-2-Chloromethyl-3-methyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrachloromethane; triphenylphosphine;
for 15h;
Heating;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / acetonitrile; CH2Cl2 / -40 deg C, 6 h; room temperature, 10 h
2: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH2Cl2, reflux, 2 h, 2.) -78 deg C, 30 min
3: 83 percent / Ph3P, CCl4 / 15 h / Heating
With
tetrachloromethane; dmap; oxalyl dichloride; tetrabutylammonium borohydride; dicyclohexyl-carbodiimide; triphenylphosphine;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / acetonitrile; CH2Cl2 / -40 deg C, 6 h; room temperature, 10 h
2: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH2Cl2, reflux, 2 h, 2.) -78 deg C, 30 min
3: 83 percent / Ph3P, CCl4 / 15 h / Heating
With
tetrachloromethane; dmap; oxalyl dichloride; tetrabutylammonium borohydride; dicyclohexyl-carbodiimide; triphenylphosphine;
In
dichloromethane; acetonitrile;
