3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]propane-1-sulfonyl chloride

Base Information

Chemical Name:3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]propane-1-sulfonyl chloride
CAS No.:118943-26-3
Molecular Formula:C₁₂H₁₅Cl₃O₄S
Molecular Weight:361.674
Hs Code.:2909309090
European Community (EC) Number:622-491-6
DSSTox Substance ID:DTXSID10584326
Wikidata:Q82475968
Mol file:118943-26-3.mol

Synonyms:118943-26-3;3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]propane-1-sulfonyl chloride;3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]-1-propanesulfonyl chloride;1-Propanesulfonylchloride, 3-[2,5-bis(chloromethyl)-4-methoxyphenoxy]-;3-[2,5-Bis(chloromethyl)-4-methoxy-phenoxy]propane-1-sulfonyl chloride;3-[2 5-BIS(CHLOROMETHYL)-4-METHOXYPHENO&;DTXSID10584326;AKOS016016443;3-[2,5-Bis(chloromethyl)-4-methoxy-phenoxy]propane-1-sulfonylchloride;3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]-1-propanesulfonyl chloride, 98%

Suppliers and Price of 3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]propane-1-sulfonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]-1-propanesulfonyl chloride 98%
1g
$ 298.00

American Custom Chemicals Corporation
3-[2,5-BIS(CHLOROMETHYL)-4-METHOXYPHENOXY]-1-PROPANESULFONYL CHLORIDE 95.00%
5MG
$ 502.44

Total 6 raw suppliers

Chemical Property of 3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]propane-1-sulfonyl chloride

Chemical Property:

Melting Point:97 °C (dec.)(lit.)
PSA：60.98000
LogP:4.59110
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:359.975663
Heavy Atom Count:20
Complexity:371

Purity/Quality:

99% ^*data from raw suppliers

3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]-1-propanesulfonyl chloride 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:C
Statements: 34
Safety Statements: 26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1)CCl)OCCCS(=O)(=O)Cl)CCl

Technology Process of 3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]propane-1-sulfonyl chloride

There total 3 articles about 3-[2,5-Bis(chloromethyl)-4-methoxyphenoxy]propane-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 118943-25-2
3-(4′-methoxyphenoxy)propane-1-sulfonyl chloride

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 118943-26-3
3-(2′,5′-bis(chloromethyl)-4′-methoxyphenoxy)propane-1-sulfonyl chloride

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 85 ℃; for 4h;
DOI:10.1039/c8ob01439f

Reference yield:

: 150-76-5
4-methoxy-phenol

: 118943-26-3
3-(2′,5′-bis(chloromethyl)-4′-methoxyphenoxy)propane-1-sulfonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; 1,4-dioxane

2: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3: hydrogenchloride; acetic acid / water / 4 h / 85 °C

With hydrogenchloride; thionyl chloride; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c8ob01439f

Reference yield:

: sodium 3-(4′-methoxyphenoxy)propane-1-sulfonate

: 118943-26-3
3-(2′,5′-bis(chloromethyl)-4′-methoxyphenoxy)propane-1-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2: hydrogenchloride; acetic acid / water / 4 h / 85 °C

With hydrogenchloride; thionyl chloride; acetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1039/c8ob01439f