4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt

Base Information

• Chemical Name: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt
• CAS No.: 1251952-73-4
• Molecular Formula: C₇H₈O₃S*C₁₄H₁₇N₃O₄
• Molecular Weight: 463.511
• Mol file: 1251952-73-4.mol

Synonyms:4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt

Chemical Property of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt

There total 13 articles about 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.2%

(R)-(2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzene sulfonate (1424942-80-2) → 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt (1251952-73-4)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; isopropyl alcohol; at 80 - 85 ℃; for 24h; Autoclave;

Reference yield:

4-(4-aminophenyl)morpholin-3-one (438056-69-0) → 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt (1251952-73-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / acetone; water; toluene / 4 h / 0 - 30 °C

2.1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 18 h / 30 °C

3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

4.1: ammonium hydroxide / tetrahydrofuran; isopropyl alcohol / 24 h / 80 - 85 °C / Autoclave

With methanol; ammonium hydroxide; sodium hydrogencarbonate; triethylamine; lithium tert-butoxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene;

Reference yield:

[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester (1313613-18-1) → 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt (1251952-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 18 h / 30 °C

2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

3.1: ammonium hydroxide / tetrahydrofuran; isopropyl alcohol / 24 h / 80 - 85 °C / Autoclave

With methanol; ammonium hydroxide; triethylamine; lithium tert-butoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester

4-[4-{(R)-2,3-dihydroxy-propylamino}phenyl]morpholin-3-one

butyric acid-2(R)-2-hydroxy-3-[4-(3-oxo-morpholin-4-yl)phenylamino]-propyl ester

butyric acid-2-oxo-5(R)-3-[4-(3-oxomorpholin-4-yl)-phenyl]oxazolidin-5-yl-methyl ester

Refernces