4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine

Base Information Edit

Chemical Name:4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine
CAS No.:1089279-61-7
Molecular Formula:C₁₆H₂₄N₄O₃
Molecular Weight:320.392
Hs Code.:
Mol file:1089279-61-7.mol

Synonyms:4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine

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Chemical Property of 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine Edit

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Technology Process of 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine

There total 6 articles about 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1089279-66-2
tert-butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate

: 1089279-61-7
4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 81.0%

: 761440-64-6
1-(3-methoxy-4 nitrophenyl)piperidin-4-one

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1089279-61-7
4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine

Guidance literature:: 1-(3-methoxy-4 nitrophenyl)piperidin-4-one; 1-t-Butoxycarbonylpiperazine; With acetic acid; triethylamine; In toluene; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In toluene; for 4h;

With sodium hydroxide; sodium hydrogencarbonate; trifluoroacetic acid; more than 3 stages;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1089279-61-7
4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2.1: triethylamine; acetic acid / toluene / 0.5 h / 20 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;