1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine

Base Information

Chemical Name:1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine
CAS No.:1089279-62-8
Molecular Formula:C₁₈H₂₇FN₄O₃
Molecular Weight:366.436
Hs Code.:

Synonyms:1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine

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Chemical Property of 1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine

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Technology Process of 1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine

There total 2 articles about 1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 762-51-6
1-fluoro-2-iodoethane

: 1089279-61-7
4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine

: 1089279-62-8
1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine

Guidance literature:: In tetrahydrofuran; at 85 ℃; Product distribution / selectivity; sealed tube;

Reference yield:

: 1-(2-fluoroethyl)-4-(4-piperidinyl)piperazine trihydrochloride

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1089279-62-8
1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; Product distribution / selectivity;

Reference yield: 97.0%

: 1089279-62-8
1-(2-fluoroethyl)-4-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}piperazine

: 1089279-63-9
4-{4-[4-(2-fluoroethyl)-1-piperazinyl]-1-piperidinyl}-2-(methyloxy)aniline

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 72h; Product distribution / selectivity;