8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

Base Information

Chemical Name:8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene
CAS No.:725253-48-5
Molecular Formula:C₅₄H₆₆O₁₁
Molecular Weight:891.111
Hs Code.:

8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4<i>H</i>-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[<i>f</i>]azulene

Synonyms:8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

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Chemical Property of 8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

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Technology Process of 8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

There total 15 articles about 8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 252046-22-3
(2R,3R,4S,4aS,9aS)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-2,3,4,4a,9,9a-hexahydro-6H-pyrano[3,2-b]oxepin

: 725253-48-5
8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

Guidance literature:: Multi-step reaction with 9 steps

1.1: AD-mix β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 0 °C

2.1: CSA / CH₂Cl₂ / 20 °C

3.1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

4.1: CSA / CH₂Cl₂ / 20 °C

5.1: 92 percent / KOt-Bu; n-Bu₄NI / tetrahydrofuran / 20 °C

6.1: 100 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

7.1: 92 percent / I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

8.1: 99 percent / NaH / dimethylformamide / 0 - 20 °C

9.1: 9-BBN / tetrahydrofuran / 20 °C

9.2: aq. Cs₂CO₃ / PdCl₂(dppf)*CH₂Cl₂ / tetrahydrofuran; dimethylformamide / 50 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; methanesulfonamide; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; 1,4-bis(9-O-dihydroquinidine)phthalazine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 9.1: Suzuki-Miyaura coupling / 9.2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2004.04.083

Reference yield:

: 725253-39-4
(3aS,4aS,6R,7R,8R,8aS,10aR)-7,8-Bis-benzyloxy-6-benzyloxymethyl-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

: 725253-48-5
8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

2.1: CSA / CH₂Cl₂ / 20 °C

3.1: 92 percent / KOt-Bu; n-Bu₄NI / tetrahydrofuran / 20 °C

4.1: 100 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

5.1: 92 percent / I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

6.1: 99 percent / NaH / dimethylformamide / 0 - 20 °C

7.1: 9-BBN / tetrahydrofuran / 20 °C

7.2: aq. Cs₂CO₃ / PdCl₂(dppf)*CH₂Cl₂ / tetrahydrofuran; dimethylformamide / 50 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 7.1: Suzuki-Miyaura coupling / 7.2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2004.04.083

Reference yield:

: (2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-octahydro-1,5-dioxa-benzocycloheptene-7,8-diol

: 725253-48-5
8-benzyloxy-6-(8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-ylmethyl)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

Guidance literature:: Multi-step reaction with 8 steps

1.1: CSA / CH₂Cl₂ / 20 °C

2.1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

3.1: CSA / CH₂Cl₂ / 20 °C

4.1: 92 percent / KOt-Bu; n-Bu₄NI / tetrahydrofuran / 20 °C

5.1: 100 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

6.1: 92 percent / I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

7.1: 99 percent / NaH / dimethylformamide / 0 - 20 °C

8.1: 9-BBN / tetrahydrofuran / 20 °C

8.2: aq. Cs₂CO₃ / PdCl₂(dppf)*CH₂Cl₂ / tetrahydrofuran; dimethylformamide / 50 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 8.1: Suzuki-Miyaura coupling / 8.2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2004.04.083