C₂₃H₃₈FN₃O₅S*ClH

Base Information

• Chemical Name: C₂₃H₃₈FN₃O₅S*ClH
• CAS No.: 1415548-87-6
• Molecular Formula: C₂₃H₃₈FN₃O₅S*ClH
• Molecular Weight: 524.097
• Mol file: 1415548-87-6.mol

Synonyms:C₂₃H₃₈FN₃O₅S*ClH

Chemical Property of C₂₃H₃₈FN₃O₅S*ClH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₂₃H₃₈FN₃O₅S*ClH

There total 5 articles about C₂₃H₃₈FN₃O₅S*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C28H46FN3O7S (1415548-63-8) → C23H38FN3O5S*ClH (1415548-87-6)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm301443r

Reference yield:

C22H35FN2O6S (1415548-62-7) → C23H38FN3O5S*ClH (1415548-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 0.25 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3: hydrogenchloride / dichloromethane; diethyl ether / 0.5 h / 20 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jm301443r

Reference yield:

Cbz-Leu-ψ[CH2SO2]-F (1169199-23-8) → C23H38FN3O5S*ClH (1415548-87-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen bromide; acetic acid / 0.5 h / 20 °C

1.2: Dowex-Cl / 0.08 h / 20 °C

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3.1: dichloromethane / 0.25 h / 20 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

5.1: hydrogenchloride / dichloromethane; diethyl ether / 0.5 h / 20 °C

With hydrogenchloride; hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jm301443r

upstream raw materials:

C₂₂H₃₅FN₂O₆S

C₂₈H₄₆FN₃O₇S

Cbz-Leu-ψ[CH2SO2]-F

C₆H₁₄FNO₂S