Cbz-Leu-ψ[CH2SO2]-F

Base Information

• Chemical Name: Cbz-Leu-ψ[CH2SO2]-F
• CAS No.: 1169199-23-8
• Molecular Formula: C₁₄H₂₀FNO₄S
• Molecular Weight: 317.382
• Mol file: 1169199-23-8.mol

Synonyms:Cbz-Leu-ψ[CH2SO2]-F

Chemical Property of Cbz-Leu-ψ[CH2SO2]-F

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-Leu-ψ[CH2SO2]-F

There total 10 articles about Cbz-Leu-ψ[CH2SO2]-F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

Cbz-Leu-ψ[CH2SO2]-Cl → Cbz-Leu-ψ[CH2SO2]-F (1169199-23-8)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In acetonitrile;

DOI:10.1016/j.tetlet.2009.02.130

Reference yield:

C14H21NO5S (1300858-67-6) → Cbz-Leu-ψ[CH2SO2]-F (1169199-23-8)

Guidance literature:

C₁₄H₂₁NO₅S; With 10% palladium on activated charcoal; sodium acetate; In water; at 20 ℃;

With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2011.02.014

Reference yield:

(S)-2-benzyloxycarbonylamino-4-methylpentyl thiolacetate (744265-92-7) → Cbz-Leu-ψ[CH2SO2]-F (1169199-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; dihydrogen peroxide; acetic acid / 20 °C

2.1: 10% palladium on activated charcoal; sodium acetate / water / 20 °C

2.2: 20 °C

3.1: potassium fluoride; 18-crown-6 ether / acetonitrile / 20 °C

With potassium fluoride; 18-crown-6 ether; 10% palladium on activated charcoal; water; dihydrogen peroxide; sodium acetate; acetic acid; In water; acetonitrile;

DOI:10.1016/j.bmc.2011.02.014

upstream raw materials:

(S)-2-benzyloxycarbonylamino-4-methylpentyl thiolacetate

Z-Leu-OH

C₁₄H₂₁NO₅S

(S)-(-)-N-(benzyloxycarbonyl)leucinol

Downstream raw materials:

Boc-Phe-Leu-ψ[CH2SO2]-F

PW₂₈

AJ₃₈

C₂₀H₂₅FN₄O₄S