2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine

Base Information

Chemical Name:2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine
CAS No.:79787-22-7
Molecular Formula:C₁₅H₁₅F₂NO₂
Molecular Weight:279.286
Hs Code.:

Synonyms:2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine

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Chemical Property of 2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine

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Technology Process of 2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine

There total 3 articles about 2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 79787-17-0
dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate

: 79787-22-7
2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;
DOI:10.1021/jm00343a017

Reference yield:

: 76903-88-3
3,4-difluorobenzoyl chloride

: 79787-22-7
2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH

2: 84 percent / acetic anhydride / 2 h / 140 - 150 °C

3: 65 percent / LiAlH₄ / tetrahydrofuran / Heating

With sodium hydroxide; lithium aluminium tetrahydride; acetic anhydride; In tetrahydrofuran;
DOI:10.1021/jm00343a017

Reference yield:

: (S)-1-(3,4-Difluoro-benzoyl)-pyrrolidine-2-carboxylic acid

: 79787-22-7
2,3-dihydro-5-(3,4-difluorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / acetic anhydride / 2 h / 140 - 150 °C

2: 65 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; acetic anhydride; In tetrahydrofuran;
DOI:10.1021/jm00343a017