dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate

Base Information

Chemical Name:dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate
CAS No.:79787-17-0
Molecular Formula:C₁₇H₁₅F₂NO₄
Molecular Weight:335.307
Hs Code.:

Synonyms:dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate

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Chemical Property of dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate

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Technology Process of dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate

There total 3 articles about dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (S)-1-(3,4-Difluoro-benzoyl)-pyrrolidine-2-carboxylic acid

: 762-42-5
dimethyl acetylenedicarboxylate

: 79787-17-0
dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: With acetic anhydride; at 140 - 150 ℃; for 2h;
DOI:10.1021/jm00343a017

Reference yield:

: 455-86-7
3,4-Difluorobenzoic acid

: 79787-17-0
dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / thionyl chloride / Heating

2: aq. NaOH

3: 84 percent / acetic anhydride / 2 h / 140 - 150 °C

With sodium hydroxide; thionyl chloride; acetic anhydride;
DOI:10.1021/jm00343a017

Reference yield:

: 76903-88-3
3,4-difluorobenzoyl chloride

: 79787-17-0
dimethyl 2,3-dihydro-5-(3,4-difluorophenyl)-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH

2: 84 percent / acetic anhydride / 2 h / 140 - 150 °C

With sodium hydroxide; acetic anhydride;
DOI:10.1021/jm00343a017