Cyclopenta[b]pyrrole, 1-acetyl-1,4,5,6-tetrahydro-3-methyl- (9CI)

Base Information

• Chemical Name: Cyclopenta[b]pyrrole, 1-acetyl-1,4,5,6-tetrahydro-3-methyl- (9CI)
• CAS No.: 118718-53-9
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 118718-53-9.mol

Synonyms:Cyclopenta[b]pyrrole,1-acetyl-1,4,5,6-tetrahydro-3-methyl- (9CI)

Chemical Property of Cyclopenta[b]pyrrole, 1-acetyl-1,4,5,6-tetrahydro-3-methyl- (9CI)

Chemical Property:

• PSA: 22.00000
• LogP: 1.94530

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopenta[b]pyrrole, 1-acetyl-1,4,5,6-tetrahydro-3-methyl- (9CI)

There total 3 articles about Cyclopenta[b]pyrrole, 1-acetyl-1,4,5,6-tetrahydro-3-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-Acetylamino-1-methoxy-1-methylethyl)cyclopentanone (118718-51-7,118718-52-8) → 1-(3-Methyl-5,6-dihydro-4H-cyclopenta[b]pyrrol-1-yl)-ethanone (118718-53-9)

Guidance literature:

With molecular sieve; toluene-4-sulfonic acid; In benzene; for 3h; Yield given; Heating;

DOI:10.1055/s-1988-27581

Reference yield:

N-Acetylaminoacetone dimethyl acetal (40815-56-3) → 1-(3-Methyl-5,6-dihydro-4H-cyclopenta[b]pyrrol-1-yl)-ethanone (118718-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / TiCl₄ / CH₂Cl₂ / 5 h / -78 °C

2: p-toluenesulfonic acid, molecular sieves / benzene / 3 h / Heating

With molecular sieve; titanium tetrachloride; toluene-4-sulfonic acid; In dichloromethane; benzene;

DOI:10.1055/s-1988-27581

Reference yield:

1-(trimethylsilyloxy)cyclopentene (19980-43-9) → 1-(3-Methyl-5,6-dihydro-4H-cyclopenta[b]pyrrol-1-yl)-ethanone (118718-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / TiCl₄ / CH₂Cl₂ / 5 h / -78 °C

2: p-toluenesulfonic acid, molecular sieves / benzene / 3 h / Heating

With molecular sieve; titanium tetrachloride; toluene-4-sulfonic acid; In dichloromethane; benzene;

DOI:10.1055/s-1988-27581

upstream raw materials:

2-(2-Acetylamino-1-methoxy-1-methylethyl)cyclopentanone

N-Acetylaminoacetone dimethyl acetal

1-(trimethylsilyloxy)cyclopentene

Refernces